{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T14:08:58Z","timestamp":1793369338434,"version":"4.5.0"},"reference-count":56,"publisher":"National Academy of Sciences","issue":"25","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG017265"],"award-info":[{"award-number":["P30AG017265"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG AG060110"],"award-info":[{"award-number":["R01 AG AG060110"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,6,21]]},"abstract":"<jats:p>\n                    Exposure to stress is a risk factor for poor health and accelerated aging. Immune aging, including declines in na\u00efve and increases in terminally differentiated T cells, plays a role in immune health and tissue specific aging, and may contribute to elevated risk for poor health among those who experience high psychosocial stress. Past data have been limited in estimating the contribution of life stress to the development of accelerated immune aging and investigating mediators such as lifestyle and cytomegalovirus (CMV) infection. This study utilizes a national sample of 5,744 US adults over age 50 to assess the relationship of social stress (viz., everyday discrimination, stressful life events, lifetime discrimination, life trauma, and chronic stress) with flow cytometric estimates of immune aging, including na\u00efve and terminally differentiated T cell percentages and the ratio of CD4\n                    <jats:sup>+<\/jats:sup>\n                    to CD8\n                    <jats:sup>+<\/jats:sup>\n                    cells. Experiencing life trauma and chronic stress was related to a lower percentage of CD4\n                    <jats:sup>+<\/jats:sup>\n                    na\u00efve cells. Discrimination and chronic stress were each associated with a greater percentage of terminally differentiated CD4\n                    <jats:sup>+<\/jats:sup>\n                    cells. Stressful life events, high lifetime discrimination, and life trauma were related to a lower percentage of CD8\n                    <jats:sup>+<\/jats:sup>\n                    na\u00efve cells. Stressful life events, high lifetime discrimination, and chronic stress were associated with a higher percentage of terminally differentiated CD8\n                    <jats:sup>+<\/jats:sup>\n                    cells. High lifetime discrimination and chronic stress were related to a lower CD4\n                    <jats:sup>+<\/jats:sup>\n                    :CD8\n                    <jats:sup>+<\/jats:sup>\n                    ratio. Lifestyle factors and CMV seropositivity partially reduced these effects. Results identify psychosocial stress as a contributor to accelerating immune aging by decreasing na\u00efve and increasing terminally differentiated T cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2202780119","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T15:14:11Z","timestamp":1655133251000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":84,"title":["Social stressors associated with age-related T lymphocyte percentages in older US adults: Evidence from the US Health and Retirement Study"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0019-1332","authenticated-orcid":false,"given":"Eric T.","family":"Klopack","sequence":"first","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen M.","family":"Crimmins","sequence":"additional","affiliation":[{"name":"Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7168-8039","authenticated-orcid":false,"given":"Steve W.","family":"Cole","sequence":"additional","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology, Jane &amp; Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-4239","authenticated-orcid":false,"given":"Teresa E.","family":"Seeman","sequence":"additional","affiliation":[{"name":"Division of Geriatrics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-0819","authenticated-orcid":false,"given":"Judith E.","family":"Carroll","sequence":"additional","affiliation":[{"name":"Cousins Center for Psychoneuroimmunology, Department of Psychiatry &amp; Biobehavioral Sciences, Jane &amp; Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-1021-9_1"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.189"},{"key":"e_1_3_4_3_2","volume-title":"Scientists Making a Difference: The Greatest Living Behavioral and Brain Scientists Talk about Their Most Important Contributions","author":"Cohen S.","year":"2016","unstructured":"S. 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