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There are 53 genes that show mutational bias, including enrichments for missense (\n                    <jats:italic>n<\/jats:italic>\n                    = 41) or truncating (\n                    <jats:italic>n<\/jats:italic>\n                    = 12) DNVs. We also find 10 genes with evidence of male- or female-bias enrichment, including 4 X chromosome genes with significant female burden (\n                    <jats:italic>DDX3X<\/jats:italic>\n                    ,\n                    <jats:italic>MECP2<\/jats:italic>\n                    ,\n                    <jats:italic>WDR45<\/jats:italic>\n                    , and\n                    <jats:italic>HDAC8)<\/jats:italic>\n                    . This large-scale integrative analysis identifies candidates and functional subsets of NDD genes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2203491119","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T13:48:31Z","timestamp":1668001711000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":76,"title":["Integrated gene analyses of de novo variants from 46,612 trios with autism and developmental disorders"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5179-087X","authenticated-orcid":false,"given":"Tianyun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA 98195"},{"name":"Department of Medical Genetics, Center for Medical Genetics, Peking University Health Science Center, Beijing, 100191, China"},{"name":"Neuroscience Research Institute, Peking 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