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These results identify a shared genetic basis for isolated microtia and other craniofacial abnormalities and account for, at least in part, the increased incidence of microtia in Amerindigenous\u00a0populations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2203928119","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T13:31:30Z","timestamp":1652880690000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["An ancient founder mutation located between\n                    <i>ROBO1<\/i>\n                    and\n                    <i>ROBO2<\/i>\n                    is responsible for increased microtia risk in Amerindigenous populations"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4224-7277","authenticated-orcid":false,"given":"Daniel","family":"Quiat","sequence":"first","affiliation":[{"name":"Department of Cardiology, Boston Children\u2019s Hospital, Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7816-2646","authenticated-orcid":false,"given":"Sarah U.","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"},{"name":"Division of Newborn Medicine, Department of Medicine, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-5540","authenticated-orcid":false,"given":"Alexandre C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"},{"name":"Laboratory of Genetics and Molecular Cardiology, Heart Institute, Medical School of University of Sao Paulo, Sao Paulo, 05508-060, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-5016","authenticated-orcid":false,"given":"Steven R.","family":"DePalma","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon A. L.","family":"Willcox","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4257-8623","authenticated-orcid":false,"given":"Barbara","family":"McDonough","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"DeLaughter","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Gorham","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin J.","family":"Curran","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Tumblin","sequence":"additional","affiliation":[{"name":"Ear Community, Inc., Broomfield, CO 80038"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamileth","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Texas ENT Specialists, Houston, TX 77338"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Artunduaga","sequence":"additional","affiliation":[{"name":"Respira Labs, Inc., Mountain View, CA 94040"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Quintanilla-Dieck","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Oregon Health &amp; Science University, Portland, OR 97239"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Osorno","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, Universidad Nacional de Colombia, Bogot\u00e1, 111321, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Serrano","sequence":"additional","affiliation":[{"name":"Audio-Centro, Cuenca, 010107, Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usama","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Global Smile Foundation, Norwood, MA 02062"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland D.","family":"Eavey","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN 37232"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-1209","authenticated-orcid":false,"given":"Christine E.","family":"Seidman","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115"},{"name":"Cardiovascular Division, Brigham and Women\u2019s Hospital, Boston, MA 02115"},{"name":"HHMI, Chevy Chase, MD 20815"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9082-3566","authenticated-orcid":false,"given":"J. 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