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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,8,23]]},"abstract":"<jats:p>\n                    Malaria remains a global driver of morbidity and mortality. To generate new antimalarials, one must elucidate the fundamental cell biology of\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , the parasite responsible for the deadliest cases of malaria. A membranous and proteinaceous scaffold called the inner membrane complex (IMC) supports the parasite during morphological changes, including segmentation of daughter cells during asexual replication and formation of transmission-stage gametocytes. The basal complex lines the edge of the IMC during segmentation and likely facilitates IMC expansion. It is unknown, however, what drives IMC expansion during gametocytogenesis. We describe the discovery of a basal complex protein, PfBLEB, which we find to be essential for gametocytogenesis. Parasites lacking PfBLEB harbor defects in IMC expansion and are unable to form mature gametocytes. This article demonstrates a role for a basal complex protein outside of asexual division, and, importantly, highlights a potential molecular target for the ablation of malaria transmission.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2204167119","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T13:35:16Z","timestamp":1660656916000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["Identification of basal complex protein that is essential for maturation of transmission-stage malaria parasites"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9726-1554","authenticated-orcid":false,"given":"Rebecca L.","family":"Clements","sequence":"first","affiliation":[{"name":"Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115"},{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Morano","sequence":"additional","affiliation":[{"name":"Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115"},{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca M.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Biological and Biomedical Sciences, Harvard Medical School, Boston, MA 02115"},{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0225-1172","authenticated-orcid":false,"given":"James P.","family":"McGee","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"},{"name":"Department of Biochemistry and Molecular Biology, the Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esrah W.","family":"Du","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Streva","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-3726","authenticated-orcid":false,"given":"Scott E.","family":"Lindner","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, the Huck Center for Malaria Research, Pennsylvania State University, University Park, PA 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5883-7271","authenticated-orcid":false,"given":"Jeffrey D.","family":"Dvorin","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Boston Children\u2019s Hospital, Boston, MA 02115"},{"name":"Department of Pediatrics, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"World Health Organization World malaria report 2021. https:\/\/www.who.int\/teams\/global-malaria-programme\/reports\/world-malaria-report-2021. 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