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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,6,28]]},"abstract":"<jats:p>\n                    Beh\u00e7et\u2019s disease (BD) is a chronic vasculitis characterized by systemic immune aberrations. However, a comprehensive understanding of immune disturbances in BD and how they contribute to BD pathogenesis is lacking. Here, we performed single-cell and bulk RNA sequencing to profile peripheral blood mononuclear cells (PBMCs) and isolated monocytes from BD patients and healthy donors. We observed prominent expansion and transcriptional changes in monocytes in PBMCs from BD patients. Deciphering the monocyte heterogeneity revealed the accumulation of C1q-high (C1q\n                    <jats:sup>hi<\/jats:sup>\n                    ) monocytes in BD. Pseudotime inference indicated that BD monocytes markedly shifted their differentiation toward inflammation-accompanied and C1q\n                    <jats:sup>hi<\/jats:sup>\n                    monocyte\u2013ended trajectory. Further experiments showed that C1q\n                    <jats:sup>hi<\/jats:sup>\n                    monocytes enhanced phagocytosis and proinflammatory cytokine secretion, and multiplatform analyses revealed the significant clinical relevance of this subtype. Mechanistically, C1q\n                    <jats:sup>hi<\/jats:sup>\n                    monocytes were induced by activated interferon-\u03b3 (IFN-\u03b3) signaling in BD patients and were decreased by tofacitinib treatment. Our study illustrates the BD immune landscape and the unrecognized contribution of C1q\n                    <jats:sup>hi<\/jats:sup>\n                    monocytes to BD hyperinflammation, showing their potential as therapeutic targets and clinical assessment indexes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2204289119","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T15:03:30Z","timestamp":1655823810000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":88,"title":["Single-cell analyses highlight the proinflammatory contribution of C1q-high monocytes to Beh\u00e7et\u2019s disease"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3165-8185","authenticated-orcid":false,"given":"Wenjie","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7833-6108","authenticated-orcid":false,"given":"Xiaoman","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2150-7540","authenticated-orcid":false,"given":"Jinjing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, China"},{"name":"School of Nursing, Chinese Academy of Medical Sciences and Peking Union Medical College, 100144 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heping","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijun","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, 100850 Beijing, China"},{"name":"Beijing Key Laboratory of Therapeutic Gene Engineering Antibody, 100850 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoya","family":"Pei","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, 100005 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoran","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical 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100730 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengchun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenfei","family":"Wang","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy, Tongji Hospital, Frontier Science Center for Stem Cells, School of Life Science and Technology, Tongji University, 200092 Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0641-2837","authenticated-orcid":false,"given":"Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS&amp;PUMC), 100730 Beijing, China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science and Technology, 100730 Beijing, China"},{"name":"State Key Laboratory of Complex Severe and Rare Diseases, PUMCH, Chinese Academy of Medical Sciences and Peking Union Medical College, 100730 Beijing, China"},{"name":"Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, 100730 Beijing, 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