{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:41:49Z","timestamp":1790797309261,"version":"4.1.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"23","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,11,7]]},"abstract":"<jats:p>\n                    Chronic beryllium disease results from beryllium exposure in the workplace and is characterized by CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell-mediated inflammation in the lung. Susceptibility to this disease is associated with particular HLA-DP alleles. We isolated beryllium-specific T cell lines from the lungs of affected patients. These CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell lines specifically responded to beryllium in culture in the presence of antigen-presenting cells that expressed class II MHC molecules HLA-DR, -DQ, and -DP. The response to beryllium was nearly completely and selectively blocked by mAb to HLA-DP. Additional studies showed that only certain HLA-DP alleles allowed presentation of beryllium. Overall, the DP alleles that presented beryllium to disease-specific T cell lines match those implicated in disease susceptibility, providing a mechanism for this association. Based on amino acid residues shared by these restricting and susceptibility DP alleles, our results provide insight into the residues of the DP \u03b2-chain required for beryllium presentation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.220430797","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:45:09Z","timestamp":1027680309000},"page":"12717-12722","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":108,"title":["Beryllium presentation to CD4\n                    <sup>+<\/sup>\n                    T cells underlies disease-susceptibility HLA-DP alleles in chronic beryllium disease"],"prefix":"10.1073","volume":"97","author":[{"given":"Andrew P.","family":"Fontenot","sequence":"first","affiliation":[{"name":"Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262; Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206; and Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaelann","family":"Torres","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262; Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206; and Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 3V6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262; Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206; and Faculty of Medicine, Memorial University of Newfoundland, St. John's, Newfoundland, Canada A1B 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