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While the cerebellum has been found to be involved in fear conditioning, its role in emotional enhancement of episodic memory is less clear. To address this issue, we used a whole-brain functional MRI approach in 1,418 healthy participants. First, we identified clusters significantly activated during enhanced memory encoding of negative and positive emotional pictures. In addition to the well-known emotional memory\u2013related cerebral regions, we identified a cluster in the cerebellum. We then used dynamic causal modeling and identified several cerebellar connections with increased connection strength corresponding to enhanced emotional memory, including one to a cluster covering the amygdala and hippocampus, and bidirectional connections with a cluster covering the anterior cingulate cortex. The present findings indicate that the cerebellum is an integral part of a network involved in emotional enhancement of episodic memory.<\/jats:p>","DOI":"10.1073\/pnas.2204900119","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T15:17:41Z","timestamp":1664810261000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Human cerebellum and corticocerebellar connections involved in emotional memory enhancement"],"prefix":"10.1073","volume":"119","author":[{"given":"Matthias","family":"Fastenrath","sequence":"first","affiliation":[{"name":"Division of Cognitive Neuroscience, Faculty of Medicine, University of Basel, Basel, 4055, Switzerland"},{"name":"Research Platform Molecular and Cognitive Neurosciences, University of Basel, Basel, 4055, 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