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Linear combinations of melanopsin (ipRGC), short-wavelength (S) cone, and combined long- and medium-wavelength (L+M) cone functions were also fit and compared. For melatonin suppression, lambda\n                    <jats:sub>max<\/jats:sub>\n                    was 441 nm in the first quarter of the 6.5-h exposure with a second peak at 550 nm, suggesting strong initial S and L+M cone contribution. This contribution decayed over time; lambda\n                    <jats:sub>max<\/jats:sub>\n                    was 485 nm in the final quarter of light exposure, consistent with a predominant melanopsin contribution. Similarly, for circadian resetting, lambda\n                    <jats:sub>max<\/jats:sub>\n                    ranged from 445 nm (all three functions) to 487 nm (L+M-cone and melanopsin functions only), suggesting significant S-cone contribution, consistent with recent model findings that the first few minutes of a light exposure drive the majority of the phase resetting response. These findings suggest a possible initial strong cone contribution in driving melatonin suppression and phase resetting, followed by a dominant melanopsin contribution over longer duration light exposures.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2205301119","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T10:40:05Z","timestamp":1672310405000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":73,"title":["The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5700-8391","authenticated-orcid":false,"given":"Melissa A.","family":"St Hilaire","sequence":"first","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women\u2019s Hospital, Boston, MA 02115"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-6600","authenticated-orcid":false,"given":"Mar\u00eda L.","family":"\u00c1mundad\u00f3ttir","sequence":"additional","affiliation":[{"name":"Laboratory of Integrated Performance in Design, \u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8729-0500","authenticated-orcid":false,"given":"Shadab A.","family":"Rahman","sequence":"additional","affiliation":[{"name":"Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women\u2019s Hospital, Boston, MA 02115"},{"name":"Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantha M. 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