{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:32:18Z","timestamp":1791462738691,"version":"4.3.4"},"reference-count":57,"publisher":"National Academy of Sciences","issue":"29","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,7,19]]},"abstract":"<jats:p>\n                    HLA class I (HLA-I) allotypes vary widely in their dependence on tapasin (TAPBP), an integral component of the peptide-loading complex, to present peptides on the cell surface. We identified two single-nucleotide polymorphisms that regulate\n                    <jats:italic>TAPBP<\/jats:italic>\n                    messenger RNA (mRNA) expression in Africans,\n                    <jats:italic>rs111686073<\/jats:italic>\n                    (\n                    <jats:italic>G<\/jats:italic>\n                    \/\n                    <jats:italic>C<\/jats:italic>\n                    ) and\n                    <jats:italic>rs59097151 (A<\/jats:italic>\n                    \/\n                    <jats:italic>G)<\/jats:italic>\n                    , located in an AP-2\u03b1 transcription factor binding site and a microRNA (miR)-4486 binding site, respectively.\n                    <jats:italic>rs111686073G<\/jats:italic>\n                    and\n                    <jats:italic>rs59097151A<\/jats:italic>\n                    induced significantly higher\n                    <jats:italic>TAPBP<\/jats:italic>\n                    mRNA expression relative to the alternative alleles due to higher affinity for AP-2\u03b1 and abrogation of miR-4486 binding, respectively. These variants associated with lower\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    parasite prevalence and lower incidence of clinical malaria specifically among individuals carrying tapasin-dependent HLA-I allotypes, presumably by augmenting peptide loading, whereas tapasin-independent allotypes associated with relative protection, regardless of imputed\n                    <jats:italic>TAPBP<\/jats:italic>\n                    mRNA expression levels. Thus, an attenuated course of malaria may occur through enhanced breadth and\/or magnitude of antigen presentation, an important consideration when evaluating vaccine efficacy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2205498119","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T13:51:02Z","timestamp":1657720262000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["Genetic variation that determines\n                    <i>TAPBP<\/i>\n                    expression levels associates with the course of malaria in an HLA allotype-dependent manner"],"prefix":"10.1073","volume":"119","author":[{"given":"Victoria","family":"Walker-Sperling","sequence":"first","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean C.","family":"Digitale","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, 94158"},{"name":"Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, 94143"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1737-8021","authenticated-orcid":false,"given":"Mathias","family":"Viard","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-3500","authenticated-orcid":false,"given":"Maureen P.","family":"Martin","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Bashirova","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1721-6003","authenticated-orcid":false,"given":"Yuko","family":"Yuki","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veron","family":"Ramsuran","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Smita","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Texas Biomedical Research Institute, Host Pathogen Interaction Program, San Antonio, Texas, 78227"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-8882","authenticated-orcid":false,"given":"Vivek","family":"Naranbhai","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, 4041, South Africa"},{"name":"Dana Farber Cancer Institute, Department of Medical Oncology, Boston, Massachusetts, 02215"},{"name":"MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, 02114"},{"name":"Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, 02114"},{"name":"Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-4299","authenticated-orcid":false,"given":"Hongchuan","family":"Li","sequence":"additional","affiliation":[{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"},{"name":"Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-4266","authenticated-orcid":false,"given":"Stephen K.","family":"Anderson","sequence":"additional","affiliation":[{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"},{"name":"Laboratory of Cancer Immunometabolism, Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Yum","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program,, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, 20817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Clifford","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program,, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910"},{"name":"Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, 20817"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Kibuuka","sequence":"additional","affiliation":[{"name":"Makerere University Walter Reed Project, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Ake","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program,, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmi","family":"Thomas","sequence":"additional","affiliation":[{"name":"U.S. Military HIV Research Program,, Walter Reed Army Institute of Research, Silver Spring, Maryland, 20910"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5788-6998","authenticated-orcid":false,"given":"Sarah","family":"Rowland-Jones","sequence":"additional","affiliation":[{"name":"Viral Immunology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, OX3 7FZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rek","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Arinaitwe","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9106-4234","authenticated-orcid":false,"given":"Moses","family":"Kamya","sequence":"additional","affiliation":[{"name":"Infectious Diseases Research Collaboration, Kampala, Uganda"},{"name":"Department of Medicine, Makerere University, Kampala, Uganda"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6784-1021","authenticated-orcid":false,"given":"Isabel","family":"Rodriguez-Barraquer","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret E.","family":"Feeney","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of California San Francisco, San Francisco, California, 94158"},{"name":"Department of Pediatrics, University of California San Francisco, San Francisco, California, 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2692-2180","authenticated-orcid":false,"given":"Mary","family":"Carrington","sequence":"additional","affiliation":[{"name":"Laboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, 20892"},{"name":"Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702"},{"name":"Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, 02139"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2013.06.003"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601624"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2004445117"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807656116"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0306294101"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1485"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2575"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007711"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1274476"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871520614666140825110402"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2013554117"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.4049\/jimmunol.153.12.5525","article-title":"Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line","volume":"153","author":"Greenwood R.","year":"1994","unstructured":"R. Greenwood, Y. Shimizu, G. S. Sekhon, R. DeMars, Novel allele-specific, post-translational reduction in HLA class I surface expression in a mutant human B cell line. J. Immunol. 153, 5525\u20135536 (1994).","journal-title":"J. Immunol."},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80558-0"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301670"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00304-7"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20031680"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep14928"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-190249"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.20.4040"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1629-z"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1104"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.5248604"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw116"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa698"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002167"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.14-0312"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(16)00046-1"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2205"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26415"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070307"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.2.1016"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0803489"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0158-z"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025577"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.08.011"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241800"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01358-08"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.650028"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy981"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509150"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35832"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-13-111"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaw4236"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.69577"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu638"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giab008"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1318"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/gene.2015.56"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1701700306"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1177\/1536867X1101000403"},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","unstructured":"V. Walker-Sperling . Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner. TAPBPmalaria. Github. https:\/\/github.com\/feeneylab\/TAPBPmalaria. Deposited 17 February 2022.","DOI":"10.1073\/pnas.2205498119"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2205498119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T09:07:13Z","timestamp":1676106433000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2205498119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":57,"journal-issue":{"issue":"29","published-print":{"date-parts":[[2022,7,19]]}},"alternative-id":["10.1073\/pnas.2205498119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2205498119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,13]]},"assertion":[{"value":"2022-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2205498119"}}