{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T14:00:50Z","timestamp":1793109650587,"version":"4.5.0"},"reference-count":69,"publisher":"National Academy of Sciences","issue":"35","license":[{"start":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T00:00:00Z","timestamp":1661472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022-05181"],"award-info":[{"award-number":["RGPIN-2022-05181"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project-ID 424778381 TRR 295"],"award-info":[{"award-number":["Project-ID 424778381 TRR 295"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,8,30]]},"abstract":"<jats:p>\n                    Deep brain stimulation procedures offer an invaluable opportunity to study disease through intracranial recordings from awake patients. Here, we address the relationship between single-neuron and aggregate-level (local field potential; LFP) activities in the subthalamic nucleus (STN) and thalamic ventral intermediate nucleus (Vim) of patients with Parkinson\u2019s disease (\n                    <jats:italic>n<\/jats:italic>\n                    = 19) and essential tremor (\n                    <jats:italic>n<\/jats:italic>\n                    = 16), respectively. Both disorders have been characterized by pathologically elevated LFP oscillations, as well as an increased tendency for neuronal bursting. Our findings suggest that periodic single-neuron bursts encode both pathophysiological beta (13 to 33 Hz; STN) and tremor (4 to 10 Hz; Vim) LFP oscillations, evidenced by strong time-frequency and phase-coupling relationships between the bursting and LFP signals. Spiking activity occurring outside of bursts had no relationship to the LFP. In STN, bursting activity most commonly preceded the LFP oscillation, suggesting that neuronal bursting generated within STN may give rise to an aggregate-level LFP oscillation. In Vim, LFP oscillations most commonly preceded bursting activity, suggesting that neuronal firing may be entrained by periodic afferent inputs. In both STN and Vim, the phase-coupling relationship between LFP and high-frequency oscillation (HFO) signals closely resembled the relationships between the LFP and single-neuron bursting. This suggests that periodic single-neuron bursting is likely representative of a higher spatial and temporal resolution readout of periodic increases in the amplitude of HFOs, which themselves may be a higher resolution readout of aggregate-level LFP oscillations. Overall, our results may reconcile \u201crate\u201d and \u201coscillation\u201d models of Parkinson\u2019s disease and shed light on the single-neuron basis and origin of pathophysiological oscillations in movement disorders.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2205881119","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T13:41:12Z","timestamp":1661521272000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson\u2019s disease and essential tremor"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5280-2828","authenticated-orcid":false,"given":"Maximilian","family":"Scherer","sequence":"first","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon A.","family":"Steiner","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, 10117, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, 10178, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil K.","family":"Kalia","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, M5T 1P5, Canada"},{"name":"KITE Research Institute, University Health Network, Toronto, M5G 2A2, Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, M5T 2S8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-4929","authenticated-orcid":false,"given":"Mojgan","family":"Hodaie","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, M5T 1P5, Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, M5T 2S8, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-9060","authenticated-orcid":false,"given":"Andrea A.","family":"K\u00fchn","sequence":"additional","affiliation":[{"name":"Department of Neurology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin, 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"Department of Surgery, University of Toronto, Toronto, M5T 1P5, Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, M5T 2S8, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3866-4940","authenticated-orcid":false,"given":"William D.","family":"Hutchison","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, M5T 2S8, Canada"},{"name":"Department of Physiology, University of Toronto, Toronto, M5S 1A8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4051-5397","authenticated-orcid":false,"given":"Luka","family":"Milosevic","sequence":"additional","affiliation":[{"name":"Krembil Brain Institute, University Health Network, Toronto, M5T 2S8, Canada"},{"name":"KITE Research Institute, University Health Network, Toronto, M5G 2A2, Canada"},{"name":"Center for Advancing Neurotechnological Innovation to Application (CRANIA), Toronto, M5T 2S8, Canada"},{"name":"Institute of Medical Sciences, University of Toronto, Toronto, M5S 1A8, Canada"},{"name":"Institute of Biomedical Engineering, University of Toronto, Toronto, M5S 3G9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2022,8,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04717.x"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.08-03-00754.1988"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195050387.001.0001"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3241"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00234086"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/texcom\/tgaa017"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26759"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88170"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0089-19.2019"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10156"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.2.507"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2020.105090"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110439"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.07.002"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy139"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm266"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr301"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay1769"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812171116"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.baga.2013.11.002"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3366-04.2004"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1819975116"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.02.005"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1895-14.2014"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa394"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx252"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2018.00048"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)10070-9"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(97)01151-X"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(89)90074-X"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(90)90110-V"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10358"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.004"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.11.008"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27068"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2002.97.5.1167"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh106"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27375-5"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00697.2006"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00050"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00301-2"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.04.022"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI99986"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0378-8"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214546110"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6462"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(02)02235-X"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25366-0"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-03-01033.2001"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.217489"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2012.00155"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.05.084"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15352-3"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-11-04639.2002"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1163-05.2005"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2014.00033"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07865.x"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2007.8"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2011.03598.x"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3059497"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu281"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0934-10.2010"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440407"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10155"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncom.2013.00193"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1109\/TAU.1967.1161901"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","unstructured":"M. Scherer T. Wang R. Guggenberger L. Milosevic A. Gharabaghi Directional Absolute Coherence: A phase-based measure of effective connectivity for neurophysiology data. bioRxiv Preprint. (2022). https:\/\/doi.org\/10.1101\/2022.02.07.479359 (Accessed August 10 2022).","DOI":"10.1101\/2022.02.07.479359"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","unstructured":"M. Scherer . Single-neuron bursts encode pathological oscillations in subcortical nuclei of patients with Parkinson\u2019s disease and essential tremor. bioRxiv. https:\/\/www.biorxiv.org\/content\/10.1101\/2022.04.05.486956v1. Deposited 07 April 2022.","DOI":"10.1101\/2022.04.05.486956"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2205881119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T13:41:15Z","timestamp":1661521275000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2205881119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,26]]},"references-count":69,"journal-issue":{"issue":"35","published-print":{"date-parts":[[2022,8,30]]}},"alternative-id":["10.1073\/pnas.2205881119"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2205881119","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,26]]},"assertion":[{"value":"2022-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2205881119"}}