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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:p>\n                    Acyl-coenzyme A (CoA)\u2013binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, we report that injection of a monoclonal antibody neutralizing ACBP\/DBI (\u03b1-DBI) protects the murine liver against ischemia\/reperfusion damage, intoxication by acetaminophen and concanavalin A, and nonalcoholic steatohepatitis caused by methionine\/choline-deficient diet as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. \u03b1-DBI downregulated proinflammatory and profibrotic genes and upregulated antioxidant defenses and fatty acid oxidation in the liver. The hepatoprotective effects of \u03b1-DBI were mimicked by the induction of ACBP\/DBI-specific autoantibodies, an inducible\n                    <jats:italic>Acbp\/Dbi<\/jats:italic>\n                    knockout or a constitutive\n                    <jats:italic>\n                      Gabrg2\n                      <jats:sup>F77I<\/jats:sup>\n                    <\/jats:italic>\n                    mutation that abolishes ACBP\/DBI binding to the GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptor. Liver-protective \u03b1-DBI effects were lost when autophagy was pharmacologically blocked or genetically inhibited by knockout of\n                    <jats:italic>Atg4b<\/jats:italic>\n                    . Of note, \u03b1-DBI also reduced myocardium infarction and lung fibrosis, supporting the contention that it mediates broad organ-protective effects against multiple insults.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2207344119","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T15:17:41Z","timestamp":1664810261000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":52,"title":["ACBP\/DBI protein neutralization confers autophagy-dependent organ protection through inhibition of cell loss, inflammation, and fibrosis"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3858-0966","authenticated-orcid":false,"given":"Omar","family":"Moti\u00f1o","sequence":"first","affiliation":[{"name":"Centre de Recherche des Cordeliers, Equipe Labellis\u00e9e par la Ligue contre le Cancer, Universit\u00e9 de Paris, Sorbonne Universit\u00e9, INSERM U1138, Institut 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