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KIF2A-deficient neurons exhibit aberrant electrophysiological characteristics, neuronal connectivity, and function, leading to their loss. The role of KIF2A is not limited to development, as fully mature neurons require KIF2A for survival. Our results emphasize an additional function of KIF2A and help explain how its mutations lead to brain disorders.<\/jats:p>","DOI":"10.1073\/pnas.2209714119","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T15:17:01Z","timestamp":1667834221000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["KIF2A deficiency causes early-onset neurodegeneration"],"prefix":"10.1073","volume":"119","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7008-7920","authenticated-orcid":false,"given":"Nuria","family":"Ruiz-Reig","sequence":"first","affiliation":[{"name":"Laboratory of Developmental Neurobiology, Institute of Neuroscience, Universit\u00e9 catholique de Louvain, 1200 Brussels, 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