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Lineage tracing reveals that these cells have a distinct differentiation potential from basal cells, giving rise predominantly to pulmonary neuroendocrine cells and a subset of multiciliated cells distinguished by high\n                    <jats:italic>C6<\/jats:italic>\n                    and low\n                    <jats:italic>MUC16<\/jats:italic>\n                    expression. Lineage tracing results are supported by studies using organoids and isolated cells from the lower noncartilaginous airway. We conclude that\n                    <jats:italic>SCGB3A2\/SFTPB\/CFTR<\/jats:italic>\n                    cells are enriched in the lower airways of the developing human lung and contribute to the epithelial diversity and heterogeneity in this region.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2210113120","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T13:46:08Z","timestamp":1686059168000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":34,"title":["Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2385-6712","authenticated-orcid":false,"given":"Ansley S.","family":"Conchola","sequence":"first","affiliation":[{"name":"Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3452-8762","authenticated-orcid":false,"given":"Tristan","family":"Frum","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggy P.","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109"},{"name":"Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamika","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-5274","authenticated-orcid":false,"given":"Michael S.","family":"Downey","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109"},{"name":"Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-2420","authenticated-orcid":false,"given":"Renee F. 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