{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:27:37Z","timestamp":1793226457361,"version":"4.5.0"},"reference-count":98,"publisher":"National Academy of Sciences","issue":"19","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT2003393"],"award-info":[{"award-number":["GNT2003393"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1144807 GNT1146952"],"award-info":[{"award-number":["GNT1144807 GNT1146952"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1068866 GNT1129861"],"award-info":[{"award-number":["GNT1068866 GNT1129861"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1164577"],"award-info":[{"award-number":["GNT1164577"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1117596"],"award-info":[{"award-number":["GNT1117596"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"DHAC | National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1079004"],"award-info":[{"award-number":["GNT1079004"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000970","name":"Stem Cells Australia","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100000970","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stafford Fox Medical Research Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF21CC0073729"],"award-info":[{"award-number":["NNF21CC0073729"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,5,9]]},"abstract":"<jats:p>Chondrocytes and osteoblasts differentiated from induced pluripotent stem cells (iPSCs) will provide insights into skeletal development and genetic skeletal disorders and will generate cells for regenerative medicine applications. Here, we describe a method that directs iPSC-derived sclerotome to chondroprogenitors in 3D pellet culture then to articular chondrocytes or, alternatively, along the growth plate cartilage pathway to become hypertrophic chondrocytes that can transition to osteoblasts. Osteogenic organoids deposit and mineralize a collagen I extracellular matrix (ECM), mirroring in\u00a0vivo endochondral bone formation. We have identified gene expression signatures at key developmental stages including chondrocyte maturation, hypertrophy, and transition to osteoblasts and show that this system can be used to model genetic cartilage and bone disorders.<\/jats:p>","DOI":"10.1073\/pnas.2211510120","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T15:11:27Z","timestamp":1682953887000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":80,"title":["Modeling human skeletal development using human pluripotent stem cells"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2938-2711","authenticated-orcid":false,"given":"Shireen R.","family":"Lamand\u00e9","sequence":"first","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth S.","family":"Ng","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-8562","authenticated-orcid":false,"given":"Trevor L.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1959-7009","authenticated-orcid":false,"given":"Louise H. W.","family":"Kung","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Sampurno","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8395-9708","authenticated-orcid":false,"given":"Lynn","family":"Rowley","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-9744","authenticated-orcid":false,"given":"Jinia","family":"Lilianty","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4802-2685","authenticated-orcid":false,"given":"Yudha Nur","family":"Patria","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"Department of Child Health, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4794-030X","authenticated-orcid":false,"given":"Tayla","family":"Stenta","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-1844","authenticated-orcid":false,"given":"Eric","family":"Hanssen","sequence":"additional","affiliation":[{"name":"Ian Holmes Imaging Center and Department of Biochemistry and Pharmacology, Bio21 Institute, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina M.","family":"Bell","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5412-2255","authenticated-orcid":false,"given":"Ritika","family":"Saxena","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn S.","family":"Stok","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, University of Melbourne, Parkville, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6389-3665","authenticated-orcid":false,"given":"Edouard G.","family":"Stanley","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6448-8314","authenticated-orcid":false,"given":"Andrew G.","family":"Elefanty","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"},{"name":"The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-0730","authenticated-orcid":false,"given":"John F.","family":"Bateman","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute, Parkville, VIC 3052, Australia"},{"name":"Department of Paediatrics, University of Melbourne, Parkville, VIC 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.042308.113308"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01657"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008334"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21060"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","unstructured":"A. Haseeb SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation\/osteoblastic redifferentiation. Proc. Natl. Acad. Sci. U.S.A. 118 e2019152118 (2021). e2019152118","DOI":"10.1073\/pnas.2019152118"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.201411031"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302703111"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004820"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76932"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050400302"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<138::AID-BIES5>3.0.CO;2-4"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-020-0482-1"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4524"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087890"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.07.012"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1683"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3210"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep00455"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.165431"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.040"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.06.011"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2931"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20598-y"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72038-y"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aba412"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep02683"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2005.04.040"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.2174\/1574888X09666131230142459"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603516659344"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602296200"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2014.08.006"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20667"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20702"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.06.003"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/jmi.12824"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2007.01.037"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.39243"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.072332sr"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00289-1"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204037"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn125"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.10439"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.09.003"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11050-1"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.029"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.11443"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00081"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.2220\/biomedres.36.21"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007346"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4132"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-22517-1"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1186\/scrt328"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00757"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4052"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22115445"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00105.2009"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070804"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.8515"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/7.3.563"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-8-154"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.34"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29704"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.05.012"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy146"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2010.0279"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.125.19.3831"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.suppl_2.ii40"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.01.003"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2021.102515"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)36881-3"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086894"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.10.160"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101453"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.15.8642"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.33.11.965"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080934"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2021.01.014"},{"key":"e_1_3_4_78_2","unstructured":"M. Dudek The chondrocyte clock gene Bmal1 controls cartilage homeostasis andintegrity (2016). 10.1172\/JCI82755. Accessed 14 November 2022."},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2016.1158183"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12827"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1177\/1947603520903425"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2019.1620572"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2259"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-020-00650-y"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.07.015"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2018.101380"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2019.101689"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2020.101962"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2014.12.005"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.01.001"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/cmi.12132"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts167"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw354"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.9005.1"},{"key":"e_1_3_4_98_2","unstructured":"S. R. Lamand\u00e9 E. S. Ng E. G. Stanley A. G. Elefanty J. F. Bateman Human iPSC can be differentiated in\u00a0vitro to articular cartilage or to osteogenic organoids via the endochondral ossification transdifferentiation pathway. NCBI Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?&acc=GSE219215. Deposited 2 December 2022."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2211510120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T09:22:19Z","timestamp":1695288139000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2211510120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":98,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2023,5,9]]}},"alternative-id":["10.1073\/pnas.2211510120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2211510120","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2211510120"}}