{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:55:57Z","timestamp":1789757757825,"version":"4.0.1"},"reference-count":71,"publisher":"National Academy of Sciences","issue":"2","license":[{"start":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T00:00:00Z","timestamp":1672790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["K99DC018600"],"award-info":[{"award-number":["K99DC018600"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC011284"],"award-info":[{"award-number":["R01DC011284"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,1,10]]},"abstract":"<jats:p>The process by which sensory evidence contributes to perceptual choices requires an understanding of its transformation into decision variables. Here, we address this issue by evaluating the neural representation of acoustic information in the auditory cortex-recipient parietal cortex, while gerbils either performed a two-alternative forced-choice auditory discrimination task or while they passively listened to identical acoustic stimuli. During task engagement, stimulus identity decoding performance from simultaneously recorded parietal neurons significantly correlated with psychometric sensitivity. In contrast, decoding performance during passive listening was significantly reduced. Principal component and geometric analyses revealed the emergence of low-dimensional encoding of linearly separable manifolds with respect to stimulus identity and decision, but only during task engagement. These findings confirm that the parietal cortex mediates a transition of acoustic representations into decision-related variables. Finally, using a clustering analysis, we identified three functionally distinct subpopulations of neurons that each encoded task-relevant information during separate temporal segments of a trial. Taken together, our findings demonstrate how parietal cortex neurons integrate and transform encoded auditory information to guide sound-driven perceptual decisions.<\/jats:p>","DOI":"10.1073\/pnas.2212120120","type":"journal-article","created":{"date-parts":[[2023,1,4]],"date-time":"2023-01-04T13:50:10Z","timestamp":1672840210000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["Transformation of acoustic information to sensory decision variables in the parietal cortex"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-9044","authenticated-orcid":false,"given":"Justin D.","family":"Yao","sequence":"first","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"},{"name":"Department of Otolaryngology, Head and Neck Surgery, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901"},{"name":"Brain Health Institute, Rutgers University, Piscataway, NJ 08854"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klavdia O.","family":"Zemlianova","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Hocker","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3414-8244","authenticated-orcid":false,"given":"Cristina","family":"Savin","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"},{"name":"Neuroscience Institute, New York University Langone School of Medicine, New York, NY 10016"},{"name":"Center for Data Science, New York University, New York NY 10011"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine M.","family":"Constantinople","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"},{"name":"Neuroscience Institute, New York University Langone School of Medicine, New York, NY 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SueYeon","family":"Chung","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"},{"name":"Flatiron Institute, Simons Foundation, New York NY 10010"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3783-6165","authenticated-orcid":false,"given":"Dan H.","family":"Sanes","sequence":"additional","affiliation":[{"name":"Center for Neural Science, New York University, New York NY 10003"},{"name":"Neuroscience Institute, New York University Langone School of Medicine, New York, NY 10016"},{"name":"Department of Psychology, New York University, New York NY 10003"},{"name":"Department of Biology, New York University, New York NY 10003"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,1,4]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2016.01.003"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.047"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-072116-031302"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3565"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1962.sp006837"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1968.sp008455"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0179-10.2010"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.01.010"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2014.79.024844"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(98)80041-X"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.29.051605.113038"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4195"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-vision-111815-114511"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07237-3"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.4.1916"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10918"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071714-033919"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23020"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.07.021"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2014.00072"},{"key":"e_1_3_4_21_2","first-page":"146","article-title":"Cortical connectivity maps reveal anatomically distinct areas in the parietal cortex of the rat","volume":"8","author":"Wilber A. A.","year":"2014","unstructured":"A. A. Wilber , Cortical connectivity maps reveal anatomically distinct areas in the parietal cortex of the rat. Front. Neural Circuits 8, 146 (2014).","journal-title":"Front. Neural Circuits"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1683"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18617"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0105-17.2017"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2020.06.017"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.028"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-01356-z"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-21-09475.2002"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4761-07.2008"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14066"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw8347"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/26752"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4095-13.2014"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03208311"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4684-04.2005"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.05.022"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33891"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14578-5"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.10.010"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2007.06.010"},{"key":"e_1_3_4_41_2","first-page":"031003","article-title":"Classification and geometry of general perceptual manifolds","volume":"8","author":"Chung S.","year":"2018","unstructured":"S. Chung, D. D. Lee, H. Sompolinsky, Classification and geometry of general perceptual manifolds. Physical Rev. X 8, 031003 (2018).","journal-title":"Physical Rev. X"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3865"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0408-1"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.70129"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.76.3.2071"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.5.2503"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.1.330"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.1.343"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(69)90141-3"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227280"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2331"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.026"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2020.07.001"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04839-9"},{"key":"e_1_3_4_55_2","unstructured":"C. Stephenson et al . \"Untangling in invariant speech recognition\" in Advances in Neural Information Processing Systems H. Wallach H. Larochelle A. Beygelzimer F. Alch\u00e9-Buc E. Fox R. Carnett Eds. (Curran Associates Inc. Red Hook NY 2019) pp. 14391\u201314401."},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1816-9"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.3758\/BF03331981"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63490"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-019-0189-2"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5417.1158"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2001.86.5.2543"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00872.2003"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.09.019"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2740"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2016.02.002"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-016-1259-0"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.90989.2008"},{"key":"e_1_3_4_68_2","first-page":"4455","article-title":"Fast and accurate spike sorting of high-channel count probes with KiloSort","volume":"29","author":"Pachitariu M.","year":"2016","unstructured":"M. Pachitariu, N. A. K. Steinmetz, N. Shabnam, M. Carandini, K. D. Harris, Fast and accurate spike sorting of high-channel count probes with KiloSort. Adv. Neural Inform. Process. Syst. 29, 4455\u20134463 (2016).","journal-title":"Adv. Neural Inform. Process. Syst."},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4268"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00293"},{"key":"e_1_3_4_71_2","author":"Yao J. D.","unstructured":"J. D. Yao , Transformation of acoustic information to sensory decision variables in the parietal cortex. NYU Box. https:\/\/nyu.app.box.com\/folder\/167571938763?v=Yao-Zemlianova-et-al-2022. Deposited 25 Oct 2022.","journal-title":"Transformation"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2212120120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T08:43:29Z","timestamp":1695285809000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2212120120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,4]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,10]]}},"alternative-id":["10.1073\/pnas.2212120120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2212120120","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.07.05.498869","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,4]]},"assertion":[{"value":"2022-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2212120120"}}