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In brain extracts from 28 deceased donors with DS, ranging in age from 19 to 65 y, we found nearly all DS brains had readily measurable levels of A\u03b2 and tau prions. In a cross-sectional analysis of DS donor age at death, we found that the levels of A\u03b2 and tau prions increased with age. In contrast to DS brains, the levels of A\u03b2 and tau prions in the brains of 37 fAD and sAD donors decreased as a function of age at death. 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