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We found\n that CD40\u2013CD40 ligand interaction and the viral mimic of activated\n CD40, EBV latent membrane protein 1, suppress virus reactivation. Both\n inhibit anti-IgM or phorbolester-induced transcription of the viral\n immediate early protein BZLF1, which controls entry into the viral\n lytic cycle. The finding that latent membrane protein 1 and CD40\n contribute to the regulation of latency may have important implications\n for the balance between EBV and its host in normal as well as in\n immunocompromised individuals.<\/jats:p>","DOI":"10.1073\/pnas.221439999","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":73,"title":["Control of Epstein\u2013Barr virus reactivation by activated CD40 and viral latent membrane protein 1"],"prefix":"10.1073","volume":"99","author":[{"given":"Barbara","family":"Adler","sequence":"first","affiliation":[{"name":"GSF-National Research Center for Environment and Health, Institute\r for Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse\r 25, D-81377 Munich, 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