{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:47:07Z","timestamp":1791942427779,"version":"4.3.4"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"1","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,1,8]]},"abstract":"<jats:p>\n                    <jats:italic>Brucella melitensis<\/jats:italic>\n                    is a facultative intracellular\n bacterial pathogen that causes abortion in goats and sheep and Malta\n fever in humans. The genome of\n                    <jats:italic>B. melitensis<\/jats:italic>\n                    strain 16M\n was sequenced and found to contain 3,294,935 bp distributed over two\n circular chromosomes of 2,117,144 bp and 1,177,787 bp encoding 3,197\n ORFs. By using the bioinformatics suite ERGO,\n 2,487 (78%) ORFs were assigned functions. The origins of replication\n of the two chromosomes are similar to those of other\n \u03b1-proteobacteria. Housekeeping genes, including those involved in DNA\n replication, transcription, translation, core metabolism, and cell wall\n biosynthesis, are distributed on both chromosomes. Type I, II, and III\n secretion systems are absent, but genes encoding\n                    <jats:italic>sec<\/jats:italic>\n                    -dependent,\n                    <jats:italic>sec<\/jats:italic>\n                    -independent, and\n flagella-specific type III, type IV, and type V secretion systems as\n well as adhesins, invasins, and hemolysins were identified. Several\n features of the\n                    <jats:italic>B. melitensis<\/jats:italic>\n                    genome are similar to\n those of the symbiotic\n                    <jats:italic>Sinorhizobium meliloti<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1073\/pnas.221575398","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:36:44Z","timestamp":1027679804000},"page":"443-448","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":462,"title":["The genome sequence of the facultative intracellular pathogen\n                    <i>Brucella melitensis<\/i>"],"prefix":"10.1073","volume":"99","author":[{"given":"Vito G.","family":"DelVecchio","sequence":"first","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Kapatral","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra J.","family":"Redkar","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Patra","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Mujer","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Los","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Anderson","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamitra","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Lykidis","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Reznik","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Jablonski","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Larsen","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Bernal","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Mazur","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Goltsman","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Selkov","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip H.","family":"Elzer","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and 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Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Letesson","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Haselkorn","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Medicine, University of\r Scranton, Scranton, PA 18510; Integrated Genomics,\r Incorporated, 2201 West Campbell Park Drive, Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et 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Chicago, IL 60612;\r Department of Veterinary Science, Louisiana State\r University Ag Center, 111 Dalrymple Building, Baton Rouge, LA\r 70803; Institut National de la Sant\u00e9 et de la\r Recherche M\u00e9dicale, U431, Facult\u00e9 de M\u00e9decine, Avenue\r Kennedy, 30900 N\u00eemes, France; and Unit\u00e9 de\r Recherche en Biologie Mol\u00e9culaire, Laboratoire d'Immunologie\r et de..."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2001,12,26]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3201\/eid0302.970219","volume":"3","author":"Corbel M J","year":"1997","unstructured":"M J Corbel Emerg Infect Dis 3, 213\u2013221 (1997).","journal-title":"Emerg Infect Dis"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/clinids\/5.5.821","volume":"5","author":"Young E J","year":"1983","unstructured":"E J Young Rev Infect Dis 5, 821\u2013842 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