{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:01:54Z","timestamp":1790701314630,"version":"4.1.0"},"reference-count":61,"publisher":"National Academy of Sciences","issue":"11","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["MC_UU_12014\/12"],"award-info":[{"award-number":["MC_UU_12014\/12"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["RGP0013\/2018"],"award-info":[{"award-number":["RGP0013\/2018"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["334795\/472296"],"award-info":[{"award-number":["334795\/472296"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["217221\/Z\/19\/Z"],"award-info":[{"award-number":["217221\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:p>\n                    Transmissible vaccines are an emerging biotechnology that hold prospects to eliminate pathogens from wildlife populations. Such vaccines would genetically modify naturally occurring, nonpathogenic viruses (\u201cviral vectors\u201d) to express pathogen antigens while retaining their capacity to transmit. The epidemiology of candidate viral vectors within the target wildlife population has been notoriously challenging to resolve but underpins the selection of effective vectors prior to major investments in vaccine development. Here, we used spatiotemporally replicated deep sequencing to parameterize competing epidemiological mechanistic models of\n                    <jats:italic>Desmodus rotundus<\/jats:italic>\n                    betaherpesvirus (DrBHV), a proposed vector for a transmissible vaccine targeting vampire bat-transmitted rabies. Using 36 strain- and location-specific time series of prevalence collected over 6 y, we found that lifelong infections with cycles of latency and reactivation, combined with a high R\n                    <jats:sub>0<\/jats:sub>\n                    (6.9; CI: 4.39 to 7.85), are necessary to explain patterns of DrBHV infection observed in wild bats. These epidemiological properties suggest that DrBHV may be suited to vector a lifelong, self-boosting, and transmissible vaccine. Simulations showed that inoculating a single bat with a DrBHV-vectored rabies vaccine could immunize &gt;80% of a bat population, reducing the size, frequency, and duration of rabies outbreaks by 50 to 95%. Gradual loss of infectious vaccine from vaccinated individuals is expected but can be countered by inoculating larger but practically achievable proportions of bat populations. Parameterizing epidemiological models using accessible genomic data brings transmissible vaccines one step closer to implementation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2216667120","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T15:19:24Z","timestamp":1678115964000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":31,"title":["Inferring the disruption of rabies circulation in vampire bat populations using a betaherpesvirus-vectored transmissible vaccine"],"prefix":"10.1073","volume":"120","author":[{"given":"Megan E.","family":"Griffiths","sequence":"first","affiliation":[{"name":"Medical Research Council\u2013University of Glasgow Centre for Virus Research, Glasgow G61 1QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana K.","family":"Meza","sequence":"additional","affiliation":[{"name":"School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1240-1886","authenticated-orcid":false,"given":"Daniel T.","family":"Haydon","sequence":"additional","affiliation":[{"name":"School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7475-2705","authenticated-orcid":false,"given":"Daniel G.","family":"Streicker","sequence":"additional","affiliation":[{"name":"Medical Research Council\u2013University of Glasgow Centre for Virus Research, Glasgow G61 1QH, United Kingdom"},{"name":"School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow G61 1QH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,3,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-43210-w"},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","unstructured":"J. Maki Oral vaccination of wildlife using a vaccinia\u2013rabies-glycoprotein recombinant virus vaccine (RABORAL V-RG\u00ae): A global review. Vet. Res. 48 57 (2017).","DOI":"10.1186\/s13567-017-0459-9"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/354520a0"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2020.08.006"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-019-1032-x"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.12.037"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2017.09.007"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-020-1254-y"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(01)00184-0"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-021-01394-3"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","unstructured":"T. J. 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Griffiths, Diana K Meza, Daniel T Haydon, Daniel G Streicker, Inferring the disruption of rabies circulation in vampire bat populations using a betaherpesvirus-vectored transmissible vaccine (Preprint and revised submission data), figshare, https:\/\/doi.org\/10.6084\/m9.figshare.20764960.v2 Deposited 11 January 2023.","journal-title":"figshare"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2216667120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T09:07:29Z","timestamp":1695287249000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2216667120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,6]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,3,14]]}},"alternative-id":["10.1073\/pnas.2216667120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2216667120","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,6]]},"assertion":[{"value":"2022-09-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2216667120"}}