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These viral RNA structures promote a compact global genome architecture, interact with proteins, and regulate the viral replication cycle. These motifs are also thus constrained at the levels of both RNA structure and protein sequence and are potential resistance-refractory targets for antivirals and live-attenuated vaccines. Structure-first identification of conserved RNA structure enables efficient discovery of pervasive RNA-mediated regulation in viral genomes and, likely, other cellular RNAs.<\/jats:p>","DOI":"10.1073\/pnas.2217053120","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T15:10:27Z","timestamp":1680534627000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Structure-first identification of RNA elements that regulate dengue virus genome architecture and replication"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0092-3203","authenticated-orcid":false,"given":"Mark A.","family":"Boerneke","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599-3290"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandan 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