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Here, fMRI results revealed robust increases in global functional connectivity (GFC), network disintegration and desegregation, and a compression of the principal cortical gradient under DMT. GFC \u00d7 subjective intensity maps correlated with independent positron emission tomography (PET)-derived 5-HT2AR maps, and both overlapped with meta-analytical data implying human-specific psychological functions. Changes in major EEG-measured neurophysiological properties correlated with specific changes in various fMRI metrics, enriching our understanding of the neural basis of DMT\u2019s effects. The present findings advance on previous work by confirming a predominant action of DMT\u2014and likely other 5-HT2AR agonist psychedelics\u2014on the brain\u2019s transmodal association pole, i.e., the neurodevelopmentally and evolutionarily recent cortex that is associated with species-specific psychological advancements, and high expression of 5-HT2A receptors.<\/jats:p>","DOI":"10.1073\/pnas.2218949120","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T15:10:16Z","timestamp":1679325016000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":224,"title":["Human brain effects of DMT assessed via EEG-fMRI"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2281-377X","authenticated-orcid":false,"given":"Christopher","family":"Timmermann","sequence":"first","affiliation":[{"name":"Division of Psychiatry, Department of Brain Sciences, Centre for Psychedelic 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