{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:38:39Z","timestamp":1790638719400,"version":"4.1.0"},"reference-count":54,"publisher":"National Academy of Sciences","issue":"22","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","award":["none"],"award-info":[{"award-number":["none"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Josephine Hughes Sterling Foundation","award":["none"],"award-info":[{"award-number":["none"]}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK111430"],"award-info":[{"award-number":["DK111430"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,5,30]]},"abstract":"<jats:p>\n                    Osteolectin is a recently identified osteogenic growth factor that binds to Integrin \u03b111 (encoded by\n                    <jats:italic>Itga11<\/jats:italic>\n                    ), promoting Wnt pathway activation and osteogenic differentiation by bone marrow stromal cells. While\n                    <jats:italic>Osteolectin<\/jats:italic>\n                    and\n                    <jats:italic>Itga11<\/jats:italic>\n                    are not required for the formation of the skeleton during fetal development, they are required for the maintenance of adult bone mass. Genome-wide association studies in humans reported a single-nucleotide variant (rs182722517) 16\u00a0kb downstream of\n                    <jats:italic>Osteolectin<\/jats:italic>\n                    associated with reduced height and plasma Osteolectin levels. In this study, we tested whether Osteolectin promotes bone elongation and found that\n                    <jats:italic>Osteolectin<\/jats:italic>\n                    -deficient mice have shorter bones than those of sex-matched littermate controls. Integrin \u03b111 deficiency in limb mesenchymal progenitors or chondrocytes reduced growth plate chondrocyte proliferation and bone elongation. Recombinant Osteolectin injections increased femur length in juvenile mice. Human bone marrow stromal cells edited to contain the rs182722517 variant produced less Osteolectin and underwent less osteogenic differentiation than that of control cells. These studies identify Osteolectin\/Integrin \u03b111 as a regulator of bone elongation and body length in mice and humans.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2220159120","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T15:02:10Z","timestamp":1684767730000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":11,"title":["Osteolectin increases bone elongation and body length by promoting growth plate chondrocyte proliferation"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8811-1319","authenticated-orcid":false,"given":"Jingzhu","family":"Zhang","sequence":"first","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Du","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Davis","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Gu","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Lyu","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1988-7337","authenticated-orcid":false,"given":"Jian","family":"Xu","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1587-8329","authenticated-orcid":false,"given":"Sean J.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Children\u2019s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390"},{"name":"HHMI, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.251"},{"key":"e_1_3_4_2_2","first-page":"61","article-title":"Factors affecting bone growth","volume":"44","author":"Gkiatas I.","year":"2015","unstructured":"I. Gkiatas , Factors affecting bone growth. Am. J. Orthop. 44, 61\u201367 (2015).","journal-title":"Am. J. Orthop."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2015.165"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00324"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.020362"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.13.16.2072"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.24.5099"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0662-5"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.08.010"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34804-6"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10783"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11885"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2013.05.014"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.11.022"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.06.008"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03298-5"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3570"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.18782"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42274"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2026176118"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0175-2"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw373"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz469"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.11.008"},{"key":"e_1_3_4_25_2","first-page":"639","article-title":"DNA strand breaks occurring during apoptosis - their early insitu detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors","volume":"1","author":"Gorczyca W.","year":"1992","unstructured":"W. Gorczyca, S. Bruno, R. Darzynkiewicz, J. Gong, Z. Darzynkiewicz, DNA strand breaks occurring during apoptosis - their early insitu detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int. J. Oncol. 1, 639\u2013648 (1992).","journal-title":"Int. J. Oncol."},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302703111"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004820"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10092"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/dvg.20564","article-title":"Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage","volume":"47","author":"Henry S. P.","year":"2009","unstructured":"S. P. Henry , Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage. Genesis 47, 805\u2013814 (2009).","journal-title":"Genesis"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1402.059"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13569-018-0105-y"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glt046"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.664168"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200303158"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M107977200"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M500608200"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.213611.116"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature15393"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2493-4"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1639"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0554-8"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03124-z"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2019.11.003"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.12.002"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-14029-w"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.10.002"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.128.8.1253"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2467"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-1619-1_2"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1119-7_4"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(06)19006-0"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.003"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2220159120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T11:48:37Z","timestamp":1702468117000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2220159120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":54,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,5,30]]}},"alternative-id":["10.1073\/pnas.2220159120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2220159120","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]},"assertion":[{"value":"2022-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2220159120"}}