{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:52:20Z","timestamp":1793343140912,"version":"4.5.0"},"reference-count":74,"publisher":"National Academy of Sciences","issue":"26","license":[{"start":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T00:00:00Z","timestamp":1687219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004410","name":"European Molecular Biology Organization","doi-asserted-by":"publisher","award":["ALTF 852-2019"],"award-info":[{"award-number":["ALTF 852-2019"]}],"id":[{"id":"10.13039\/100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-RHUS-0001"],"award-info":[{"award-number":["ANR-15-RHUS-0001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INSB-04-01"],"award-info":[{"award-number":["ANR-10-INSB-04-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-65"],"award-info":[{"award-number":["ANR-10-LABX-65"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"LHW-376 Stiftung","award":["LHW-376 Stiftung"],"award-info":[{"award-number":["LHW-376 Stiftung"]}]},{"DOI":"10.13039\/100019671","name":"Fondation Pour l'Audition","doi-asserted-by":"publisher","award":["FPA IDA05"],"award-info":[{"award-number":["FPA IDA05"]}],"id":[{"id":"10.13039\/100019671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019671","name":"Fondation Pour l'Audition","doi-asserted-by":"publisher","award":["FPA IDA03"],"award-info":[{"award-number":["FPA IDA03"]}],"id":[{"id":"10.13039\/100019671","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sensorion","award":["Sensorion"],"award-info":[{"award-number":["Sensorion"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-RHUS-0007"],"award-info":[{"award-number":["ANR-18-RHUS-0007"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,6,27]]},"abstract":"<jats:p>\n                    Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a result, the search for curative treatments, which are sorely lacking in the hearing field, has become a potentially achievable objective, particularly\n                    <jats:italic>via<\/jats:italic>\n                    cochlear gene and cell therapies. To this end, a complete inventory of cochlear cell types, with an in-depth characterization of their gene expression profiles right up to their final differentiation, is indispensable. We therefore generated a single-cell transcriptomic atlas of the mouse cochlea based on an analysis of more than 120,000 cells on postnatal day 8 (P8), during the prehearing period, P12, corresponding to hearing onset, and P20, when cochlear maturation is almost complete. By combining whole-cell and nuclear transcript analyses with extensive in situ RNA hybridization assays, we characterized the transcriptomic signatures covering nearly all cochlear cell types and developed cell type\u2013specific markers. Three cell types were discovered; two of them contribute to the modiolus which houses the primary auditory neurons and blood vessels, and the third one consists in cells lining the scala vestibuli. The results also shed light on the molecular basis of the tonotopic gradient of the biophysical characteristics of the basilar membrane that critically underlies cochlear passive sound frequency analysis. Finally, overlooked expression of deafness genes in several cochlear cell types was also unveiled. This atlas paves the way for the deciphering of the gene regulatory networks controlling cochlear cell differentiation and maturation, essential for the development of effective targeted treatments.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2221744120","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:54:41Z","timestamp":1687269281000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":89,"title":["Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies"],"prefix":"10.1073","volume":"120","author":[{"given":"Philippe","family":"Jean","sequence":"first","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2316-9947","authenticated-orcid":false,"given":"Fabienne","family":"Wong Jun Tai","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-6438","authenticated-orcid":false,"given":"Amrit","family":"Singh-Estivalet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-5411","authenticated-orcid":false,"given":"Andrea","family":"Lelli","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Scandola","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Ultrastructural BioImaging, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Megharba","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Cytometry and Biomarkers, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Schmutz","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Cytometry and Biomarkers, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Roux","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Mechaussier","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Sudres","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enguerran","family":"Mouly","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Val\u00e9rie","family":"Heritier","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-9119","authenticated-orcid":false,"given":"Crystel","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-7308","authenticated-orcid":false,"given":"Adeline","family":"Mallet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Ultrastructural BioImaging, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Novault","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Cytometry and Biomarkers, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Libri","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, Cytometry and Biomarkers, F-75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9069-002X","authenticated-orcid":false,"given":"Christine","family":"Petit","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Auditory Therapies Innovation Laboratory, F-75012 Paris, France"},{"name":"Coll\u00e8ge de France, F-75005 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1287-2709","authenticated-orcid":false,"given":"Nicolas","family":"Michalski","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM, Institut de l\u2019Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,6,20]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2015.07.007"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-37101-8.00007-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.05.019"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817537116"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708894114"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0500-9"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75238-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00316"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00013"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.007"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.008"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06033-3"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31580-1"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-021-01200-9"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16113-y"},{"key":"e_1_3_4_16_2","first-page":"17","volume-title":"Hearing Loss: Mechanisms, Prevention and Cure, Advances in Experimental Medicine and Biology","author":"Guo J.","year":"2019","unstructured":"J. Guo, R. Chai, H. Li, S. Sun, \u201cProtection of hair cells from ototoxic drug-induced hearing loss\u201d in Hearing Loss: Mechanisms, Prevention and Cure, Advances in Experimental Medicine and Biology, H. Li, R. Chai, Eds. (Springer Singapore, 2019), pp. 17\u201336."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109758"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/procel\/pwac058"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00532"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90160-2"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9085-x"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.78.2.188"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1984.00800310021004"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-2-30"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/35107099"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.107.3.453"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.08.030"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.11.796"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2122121119"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-021-02311-1"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2179-14.2015"},{"key":"e_1_3_4_32_2","doi-asserted-by":"crossref","unstructured":"N. Michalski Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses. Elife 6 e31013 (2017). e31013","DOI":"10.7554\/eLife.31013"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01059"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0728-4"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902781116"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.079"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.092"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.5115\/acb.2011.44.1.69"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-012-1456-y"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.082515999"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00356"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.02.053"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515228112"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.678113"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.08.005"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24744"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094580"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10496"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097191"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/978-3-642-23499-6_531","volume-title":"Encyclopedia of Otolaryngology, Head and Neck Surgery","author":"Oliver E. R.","year":"2013","unstructured":"E. R. Oliver, B. W. Kesser, \u201cEmbryology of ear (General)\u201d in Encyclopedia of Otolaryngology, Head and Neck Surgery, S. E. Kountakis, Ed. (Springer, 2013), pp. 743\u2013749."},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","unstructured":"I. J. Russell Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound. Sci. Adv. 6 eaba2634 (2020). eaba2634","DOI":"10.1126\/sciadv.aba2634"},{"key":"e_1_3_4_52_2","volume-title":"Experiments in Hearing","author":"von B\u00e9k\u00e9sy G.","year":"1960","unstructured":"G. von B\u00e9k\u00e9sy, E. G. Wever, Experiments in Hearing (McGraw-Hill, 1960)."},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208756"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature14259"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087528"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2013.03.008"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.06.068"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4840"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2017.08.034"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3859-05.2006"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/bs.ctdb.2018.02.006","volume-title":"Current Topics in Developmental Biology, Extracellular Matrix and Egg Coats","author":"Goodyear R. J.","year":"2018","unstructured":"R. J. Goodyear, G. P. Richardson, \u201cChapter Six\u2013Structure, function, and development of the tectorial membrane: An extracellular matrix essential for hearing\u201d in Current Topics in Developmental Biology, Extracellular Matrix and Egg Coats, E. S. Litscher, P. M. Wassarman, Eds. (Academic Press, 2018), pp. 217\u2013244."},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084189"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012765"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87150-w"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.302"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg216"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.043612"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy431"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24186"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23442"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","unstructured":"C. Petit C. Bonnet S. Safieddine Deafness: From genetic architecture to gene therapy. Nat. Rev. Genet. https:\/\/doi.org\/10.1038\/s41576-023-00597-7 (2023).","DOI":"10.1038\/s41576-023-00597-7"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2022.962106"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-017-0634-8"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.652215"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2221744120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T09:06:01Z","timestamp":1695287161000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2221744120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,20]]},"references-count":74,"journal-issue":{"issue":"26","published-print":{"date-parts":[[2023,6,27]]}},"alternative-id":["10.1073\/pnas.2221744120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2221744120","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,20]]},"assertion":[{"value":"2023-01-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2221744120"}}