{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:51:18Z","timestamp":1781103078759,"version":"3.54.1"},"reference-count":12,"publisher":"National Academy of Sciences","issue":"22","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"MEXT | Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H05678"],"award-info":[{"award-number":["20H05678"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011041","name":"Asahi Group | Asahi Group Foundation","doi-asserted-by":"publisher","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"10.13039\/100011041","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Terumo Life Science Foundation","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"Research Support Program, SEKISUI CHEMICAL CO., LTD.","award":["None"],"award-info":[{"award-number":["None"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,5,30]]},"abstract":"<jats:p>\n                    Mast cells play pivotal roles in innate host defenses against venom. Activated mast cells release large amounts of prostaglandin D\n                    <jats:sub>2<\/jats:sub>\n                    (PGD\n                    <jats:sub>2<\/jats:sub>\n                    ). However, the role of PGD\n                    <jats:sub>2<\/jats:sub>\n                    in such host defense remains unclear. We found that c-kit-dependent and c-kit-independent mast cell\u2013specific hematopoietic prostaglandin D synthase (\n                    <jats:italic>H-pgds<\/jats:italic>\n                    ) deficiency significantly exacerbated honey bee venom (BV)\u2013induced hypothermia and increased mortality rates in mice. BV absorption via postcapillary venules in the skin was accelerated upon endothelial barrier disruption resulting in increased plasma venom concentrations. These results suggest that mast cell\u2013derived PGD\n                    <jats:sub>2<\/jats:sub>\n                    may enhance host defense against BV and save lives by inhibiting BV absorption into circulation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2300284120","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T15:02:10Z","timestamp":1684767730000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":4,"title":["Mast cell-derived prostaglandin D\n                    <sub>2<\/sub>\n                    limits the subcutaneous absorption of honey bee venom in mice"],"prefix":"10.1073","volume":"120","author":[{"given":"Yuki","family":"Fujiwara","sequence":"first","affiliation":[{"name":"Laboratory of\u00a0Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Laboratory of\u00a0Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toko","family":"Maehara","sequence":"additional","affiliation":[{"name":"Laboratory of\u00a0Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Laboratory of\u00a0Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Aritake","sequence":"additional","affiliation":[{"name":"Laboratory of\u00a0Chemical Pharmacology, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3328-0796","authenticated-orcid":false,"given":"Takahisa","family":"Murata","sequence":"additional","affiliation":[{"name":"Laboratory of\u00a0Animal Radiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128877"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.106.1.233"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI46139"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2017.02.030"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.112.300993"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62055-X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.06.008"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/all.14852"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.129.4.1627"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.10.005"},{"key":"e_1_3_3_11_2","doi-asserted-by":"crossref","unstructured":"M. Kida T. Nakamura Y. Fujiwara M. Nakamura T. Murata PGD 2 \/CRTH 2 signaling promotes acquired immunity against bee venom by enhancing IgE production. FASEB J. 35 e21616 (2021). e21616","DOI":"10.1096\/fj.202002748RR"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.10.1135"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2300284120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,21]],"date-time":"2023-09-21T09:20:20Z","timestamp":1695288020000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2300284120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,22]]},"references-count":12,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2023,5,30]]}},"alternative-id":["10.1073\/pnas.2300284120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2300284120","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742654639.793599061","asserted-by":"object"}]},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,22]]},"assertion":[{"value":"2023-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2300284120"}}