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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,11,14]]},"abstract":"<jats:p>Reading danger signals may save an animal\u2019s life, and learning about threats from others allows avoiding first-hand aversive and often fatal experiences. Fear expressed by other individuals, including those belonging to other species, may indicate the presence of a threat in the environment and is an important social cue. Humans and other animals respond to conspecifics\u2019 fear with increased activity of the amygdala, the brain structure crucial for detecting threats and mounting an appropriate response to them. It is unclear, however, whether the cross-species transmission of threat information involves similar mechanisms, e.g., whether animals respond to the aversively induced emotional arousal of humans with activation of fear-processing circuits in the brain. Here, we report that when rats interact with a human caregiver who had recently undergone fear conditioning, they show risk assessment behavior and enhanced amygdala activation. The amygdala response involves its two major parts, the basolateral and central, which detect a threat and orchestrate defensive responses. Further, we show that humans who learn about a threat by observing another aversively aroused human, similar to rats, activate the basolateral and centromedial parts of the amygdala. Our results demonstrate that rats detect the emotional arousal of recently aversively stimulated caregivers and suggest that cross-species social transmission of threat information may involve similar neural circuits in the amygdala as the within-species transmission.<\/jats:p>","DOI":"10.1073\/pnas.2302655120","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:59:04Z","timestamp":1699365544000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":14,"title":["Rats respond to aversive emotional arousal of human handlers with the activation of the basolateral and central amygdala"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0382-2259","authenticated-orcid":false,"given":"Anna M.","family":"Ka\u017amierowska","sequence":"first","affiliation":[{"name":"Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw 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