{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:34:44Z","timestamp":1791426884506,"version":"4.3.3"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2000,11,21]]},"abstract":"<jats:p>\n                    GABAergic (GABA = \u03b3-aminobutyric acid) neurons from\n different brain regions contain high levels of parvalbumin, both in\n their soma and in their neurites. Parvalbumin is a slow\n Ca\n                    <jats:sup>2+<\/jats:sup>\n                    buffer that may affect the amplitude and time course\n of intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transients in terminals after an\n action potential, and hence may regulate short-term synaptic\n plasticity. To test this possibility, we have applied paired-pulse\n stimulations (with 30- to 300-ms intervals) at GABAergic synapses\n between interneurons and Purkinje cells, both in wild-type (PV+\/+)\n mice and in parvalbumin knockout (PV\u2212\/\u2212) mice. We observed\n paired-pulse depression in PV+\/+ mice, but paired-pulse facilitation\n in PV\u2212\/\u2212 mice. In paired recordings of connected\n interneuron-Purkinje cells, dialysis of the presynaptic interneuron\n with the slow Ca\n                    <jats:sup>2+<\/jats:sup>\n                    buffer EGTA (1 mM) rescues paired-pulse\n depression in PV\u2212\/\u2212 mice. These data show that parvalbumin potently\n modulates short-term synaptic plasticity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.230362997","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:31:39Z","timestamp":1027679499000},"page":"13372-13377","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":366,"title":["Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity"],"prefix":"10.1073","volume":"97","author":[{"given":"Olivier","family":"Caillard","sequence":"first","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Moreno","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat","family":"Schwaller","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Llano","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco R.","family":"Celio","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Marty","sequence":"additional","affiliation":[{"name":"Max-Planck-Institute for Biophysical Chemistry, D37 077\r G\u00f6ttingen, Germany; New York University, New York,\r NY 10016; and Institute of Histology and General\r Embryology, CH 1705 Fribourg, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2000,11,7]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021204"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01374.2000"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ne.12.030189.000305"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(99)80045-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.5.1919"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(92)81872-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80983-6"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(98)90058-6"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(96)80037-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(92)90081-I"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019950"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.t01-2-00419.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90091-H"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00229363"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1999.276.2.C395"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(66)90102-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/2822"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018465"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00942742"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.2.130"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(99)00106-5"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00065.x"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021484"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-05-01675.1999"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582316"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-23-09104.1997"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-06-01496.1991"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1994.tb18836.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021334"},{"key":"e_1_3_3_30_2","volume-title":"Critical Stability Constants","author":"Martell A","year":"1977","unstructured":"A Martell, R Smith Critical Stability Constants (Plenum, New York) 2 (1977)."},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.135by.x"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.72.4.1769"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-19-05942.1996"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.23.13304"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-18-05661.1996"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-02-00645.1994"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.17-21-08137.1997"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.2.C517"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.11.5144"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(97)00632-5"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90575-X"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0143-4160(97)90064-6"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-11-04908.1993"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.1.387"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.230362997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T08:24:59Z","timestamp":1649838299000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.230362997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,11,7]]},"references-count":44,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2000,11,21]]}},"alternative-id":["10.1073\/pnas.230362997"],"URL":"https:\/\/doi.org\/10.1073\/pnas.230362997","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,11,7]]},"assertion":[{"value":"2000-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2000-11-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}