{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:16:56Z","timestamp":1793017016182,"version":"4.5.0"},"reference-count":75,"publisher":"National Academy of Sciences","issue":"44","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,10,31]]},"abstract":"<jats:p>\n                    Travel can induce motion sickness (MS) in susceptible individuals. MS is an evolutionary conserved mechanism caused by mismatches between motion-related sensory information and past visual and motion memory, triggering a malaise accompanied by hypolocomotion, hypothermia, hypophagia, and nausea. Vestibular nuclei (VN) are critical for the processing of movement input from the inner ear. Motion-induced activation of VN neurons recapitulates MS-related signs. However, the genetic identity of VN neurons mediating MS-related autonomic and aversive responses remains unknown. Here, we identify a central role of cholecystokinin (CCK)-expressing VN neurons in motion-induced malaise. Moreover, we show that CCK VN inputs onto the parabrachial nucleus activate\n                    <jats:italic toggle=\"yes\">Calca<\/jats:italic>\n                    -expressing neurons and are sufficient to establish avoidance to novel food, which is prevented by CCK-A receptor antagonism. These observations provide greater insight into the neurobiological regulation of MS by identifying the neural substrates of MS and providing potential targets for treatment.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2304933120","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T13:40:34Z","timestamp":1697550034000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Vestibular CCK signaling drives motion sickness\u2013like behavior in mice"],"prefix":"10.1073","volume":"120","author":[{"given":"Pablo","family":"Machuca-M\u00e1rquez","sequence":"first","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"S\u00e1nchez-Benito","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Menardy","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Urpi","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f2nica","family":"Girona","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Puighermanal","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Appiah","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-0582","authenticated-orcid":false,"given":"Richard D.","family":"Palmiter","sequence":"additional","affiliation":[{"name":"HHMI, University of Washington","place":["Seattle"]},{"name":"Department of Biochemistry, University of Washington","place":["Seattle"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisenda","family":"Sanz","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1674-7160","authenticated-orcid":false,"given":"Albert","family":"Quintana","sequence":"additional","affiliation":[{"name":"Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona","place":["Barcelona, Spain"]},{"name":"Focus Area for Human Metabolomics, Faculty of Natural and Agricultural Sciences, North-West University","place":["Potchefstroom, South Africa"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00014"},{"key":"e_1_3_4_2_2","first-page":"453","article-title":"Diagnostic criteria for grading the severity of acute motion sickness","volume":"39","author":"Graybiel A.","year":"1968","unstructured":"A. Graybiel, C. D. Wood, E. F. Miller, D. B. Cramer, Diagnostic criteria for grading the severity of acute motion sickness. Aerospace Med. 39, 453\u2013455 (1968).","journal-title":"Aerospace Med."},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1970.50.1.1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","unstructured":"E. Nalivaiko \u201cThermoregulation and nausea\u201d in Handbook of Clinical Neurology A. A. Romanovsky Ed. 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