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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,7,25]]},"abstract":"<jats:p>\n                    Marine algae are responsible for half of the world's primary productivity, but this critical carbon sink is often constrained by insufficient iron. One species of marine algae,\n                    <jats:italic>Dunaliella tertiolecta<\/jats:italic>\n                    , is remarkable for its ability to maintain photosynthesis and thrive in low-iron environments. A related species,\n                    <jats:italic>Dunaliella salina<\/jats:italic>\n                    Bardawil, shares this attribute but is an extremophile found in hypersaline environments. To elucidate how algae manage their iron requirements, we produced high-quality genome assemblies and transcriptomes for both species to serve as a foundation for a comparative multiomics analysis. We identified a host of iron-uptake proteins in both species, including a massive expansion of transferrins and a unique family of siderophore-iron-uptake proteins. Complementing these multiple iron-uptake routes, ferredoxin functions as a large iron reservoir that can be released by induction of flavodoxin. Proteomic analysis revealed reduced investment in the photosynthetic apparatus coupled with remodeling of antenna proteins by dramatic iron-deficiency induction of TIDI1, which is closely related but identifiably distinct from the chlorophyll binding protein, LHCA3. These combinatorial iron scavenging and sparing strategies make\n                    <jats:italic>Dunaliella<\/jats:italic>\n                    unique among photosynthetic organisms.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2305495120","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T15:12:34Z","timestamp":1689606754000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":32,"title":["Pumping iron: A multi-omics analysis of two extremophilic algae reveals iron economy management"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2698-8021","authenticated-orcid":false,"given":"Lital","family":"Davidi","sequence":"first","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 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Pacific Northwest National Laboratory, Richland, WA 99354"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Fillmore","sequence":"additional","affiliation":[{"name":"Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2461-9548","authenticated-orcid":false,"given":"Carrie D.","family":"Nicora","sequence":"additional","affiliation":[{"name":"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-0008","authenticated-orcid":false,"given":"Rory J.","family":"Craig","sequence":"additional","affiliation":[{"name":"California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7487-8014","authenticated-orcid":false,"given":"Stefan","family":"Schmollinger","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6302-5382","authenticated-orcid":false,"given":"Sanja","family":"Roje","sequence":"additional","affiliation":[{"name":"Institute of Biological Chemistry, Washington State University, Pullman, WA 99163"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-1291","authenticated-orcid":false,"given":"Crysten E.","family":"Blaby-Haas","sequence":"additional","affiliation":[{"name":"Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"},{"name":"Molecular Foundry, Lawrence Berkeley National Laboratory, Berkeley, CA 94720"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Auber","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6843-5906","authenticated-orcid":false,"given":"Jennifer H.","family":"Wisecaver","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-509X","authenticated-orcid":false,"given":"Sabeeha S.","family":"Merchant","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095"},{"name":"California Institute for Quantitative Biosciences (QB3), 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