{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:19:38Z","timestamp":1790961578291,"version":"4.1.0"},"reference-count":90,"publisher":"National Academy of Sciences","issue":"40","license":[{"start":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["MFAG-21311"],"award-info":[{"award-number":["MFAG-21311"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["5x1000-21147"],"award-info":[{"award-number":["5x1000-21147"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["IG-20766"],"award-info":[{"award-number":["IG-20766"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","award":["2020-25307 M.L"],"award-info":[{"award-number":["2020-25307 M.L"]}],"id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","award":["PTR-113-17"],"award-info":[{"award-number":["PTR-113-17"]}],"id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","award":["PTR-550-22"],"award-info":[{"award-number":["PTR-550-22"]}],"id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018694","name":"EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","award":["H2020-MSCA ITN-2019"],"award-info":[{"award-number":["H2020-MSCA ITN-2019"]}],"id":[{"id":"10.13039\/100018694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DI 764\/7-2 DI 764\/9-2"],"award-info":[{"award-number":["DI 764\/7-2 DI 764\/9-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:p>\n                    Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) require signal transducer and activator of transcription 4 (STAT4) to elicit rapid effector responses and protect against pathogens. By combining genetic and transcriptomic approaches, we uncovered divergent roles for STAT4 in regulating effector differentiation of these functionally related cell types.\n                    <jats:italic>Stat4<\/jats:italic>\n                    deletion in\n                    <jats:italic>Ncr1<\/jats:italic>\n                    -expressing cells led to impaired NK cell terminal differentiation as well as to an unexpected increased generation of cytotoxic ILC1 during intestinal inflammation. Mechanistically,\n                    <jats:italic>Stat4<\/jats:italic>\n                    -deficient ILC1 exhibited upregulation of gene modules regulated by STAT5 in vivo and an aberrant effector differentiation upon in vitro stimulation with IL-2, used as a prototypical STAT5 activator. Moreover, STAT4 expression in NCR\n                    <jats:sup>+<\/jats:sup>\n                    innate lymphocytes restrained gut inflammation in the dextran sulfate sodium-induced colitis model limiting pathogenic production of IL-13 from adaptive CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the large intestine. Collectively, our data shed light on shared and distinctive mechanisms of STAT4-regulated transcriptional control in NK cells and ILC1 required for intestinal inflammatory responses.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2306761120","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:33:06Z","timestamp":1695821586000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":18,"title":["Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-5942","authenticated-orcid":false,"given":"Gianluca","family":"Scarno","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julija","family":"Mazej","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0556-6068","authenticated-orcid":false,"given":"Mattia","family":"Laffranchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Di Censo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2922-9947","authenticated-orcid":false,"given":"Irene","family":"Mattiola","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2013Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Berlin 12203, Germany"},{"name":"Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna M.","family":"Candelotti","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Pietropaolo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Stabile","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia","family":"Fionda","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Peruzzi","sequence":"additional","affiliation":[{"name":"Center for Life Nano- &amp; Neuro-Science, Istituto Italiano di Tecnologia, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5592-5332","authenticated-orcid":false,"given":"Stephen R.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Biodata Mining and Discovery Section, Office of Science and Technology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxia Li","family":"Tsai","sequence":"additional","affiliation":[{"name":"Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-4415","authenticated-orcid":false,"given":"Yohei","family":"Mikami","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 1608582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3705-2598","authenticated-orcid":false,"given":"Giovanni","family":"Bernardini","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Gismondi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3144-8743","authenticated-orcid":false,"given":"Silvano","family":"Sozzani","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"},{"name":"Istituti di Ricovero e Cura a Carattere Scientifico Neuromed, Isernia 86077, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7146-1862","authenticated-orcid":false,"given":"James P.","family":"Di Santo","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM U1223, Paris 75724, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-8649","authenticated-orcid":false,"given":"Christian A. J.","family":"Vosshenrich","sequence":"additional","affiliation":[{"name":"Innate Immunity Unit, Institut Pasteur, Universit\u00e9 Paris Cit\u00e9, INSERM U1223, Paris 75724, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9176-9530","authenticated-orcid":false,"given":"Andreas","family":"Diefenbach","sequence":"additional","affiliation":[{"name":"Laboratory of Innate Immunity, Institute of Microbiology, Infectious Diseases and Immunology, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2013Universit\u00e4t zu Berlin, Campus Benjamin Franklin, Berlin 12203, Germany"},{"name":"Mucosal and Developmental Immunology, Deutsches Rheuma-Forschungszentrum, an Institute of the Leibniz Association, Berlin 10117, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-6736","authenticated-orcid":false,"given":"Massimo","family":"Gadina","sequence":"additional","affiliation":[{"name":"Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, NIH, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Santoni","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"},{"name":"Istituti di Ricovero e Cura a Carattere Scientifico Neuromed, Isernia 86077, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-512X","authenticated-orcid":false,"given":"Giuseppe","family":"Scium\u00e8","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Sapienza University of Rome, Rome 00161, Italy"},{"name":"Laboratory affiliated to Istituto Pasteur Italia\u2013Fondazione Cenci Bolognetti, Rome 00161, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2023,9,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.09.006"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12718"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.017"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.08.005"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.07.005"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202149209"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-01013-0"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","unstructured":"B. G. Nixon Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Sci. Immunol. 7 eabi8642 (2022). eabi8642","DOI":"10.1126\/sciimmunol.abi8642"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3800"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","unstructured":"E. Park Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells. Elife 8 e47605 (2019). e47605","DOI":"10.7554\/eLife.47605"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2020.08.009"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.029"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.04.014"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-10-187179"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201747299"},{"key":"e_1_3_4_16_2","first-page":"694","article-title":"STATs in NK-cells: The good, the bad, and the ugly","volume":"7","author":"Gotthardt D.","year":"2016","unstructured":"D. Gotthardt, V. Sexl, STATs in NK-cells: The good, the bad, and the ugly. Front. Immunol. 7, 694 (2016).","journal-title":"Front. Immunol."},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12705"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.11.016"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122097"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.03.030"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00076-7"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20131560"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25758-2"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.046"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/382171a0"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/382174a0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11813"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847480"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070401"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00211.x"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20111760"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.052"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.09.008"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0176-1"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.09.011"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01296"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2012.04.004"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3892"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01298"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izaa316"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy119"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.017"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2534"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-016-0652-3"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.06.019"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.10.017"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08949"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.140"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14782-3"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.717"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.549"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-0273-0"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201444643"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900719"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3332"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151403"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","unstructured":"K. Yomogida Hobit confers tissue-dependent programs to type 1 innate lymphoid cells. Proc. Natl. Acad. Sci. U.S.A. 118 e2117965118 (2021). e2117965118","DOI":"10.1073\/pnas.2117965118"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.09.009"},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","unstructured":"Y. Hikichi Y. Motomura O. Takeuchi K. Moro Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin. J. Exp. Med. 218 e20210181 (2021). e20210181","DOI":"10.1084\/jem.20210181"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","unstructured":"Y. S. Zhang STAT4 activation by leukemia inhibitory factor confers a therapeutic effect on intestinal inflammation. EMBO J. 38 e99595 (2019). e99595","DOI":"10.15252\/embj.201899595"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1082-x"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.01.013"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00909-1"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.170.3.827"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.1.299"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.017"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011956"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.8.1225"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1097\/00075197-200005000-00005"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21038"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.079434"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.12.014"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072774"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.573470"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.01.006"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.208"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1900750"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2015.65"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.03.017"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061099"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.05.017"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21404"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3895"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-058-8_4"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.22938"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.3791\/3678-v"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-0338-3_6"},{"key":"e_1_3_4_90_2","unstructured":"G. Scarno Data for \u201cDivergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.\u201d Gene Expression Omnibus. https:\/\/www.ncbi.nlm.nih.gov\/geo\/query\/acc.cgi?acc=GSE211129. Deposited 12 August 2022."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2306761120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T13:33:48Z","timestamp":1695821628000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2306761120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,27]]},"references-count":90,"journal-issue":{"issue":"40","published-print":{"date-parts":[[2023,10,3]]}},"alternative-id":["10.1073\/pnas.2306761120"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2306761120","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,27]]},"assertion":[{"value":"2023-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2306761120"}}