{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:19:40Z","timestamp":1791346780777,"version":"4.3.1"},"reference-count":58,"publisher":"National Academy of Sciences","issue":"13","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,3,26]]},"abstract":"<jats:p>\n                    Lactate\u2013proton symporter monocarboxylate transporter 1 (MCT1) facilitates lactic acid export from T cells. Here, we report that MCT1 is mandatory for the development of virus-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell memory. MCT1-deficient T cells were exposed to acute pneumovirus (pneumonia virus of mice, PVM) or persistent \u03b3-herpesvirus (Murid herpesvirus 4, MuHV-4) infection. MCT1 was required for the expansion of virus-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells and the control of virus replication in the acute phase of infection. This situation prevented the subsequent development of virus-specific T cell memory, a necessary step in containing virus reactivation during \u03b3-herpesvirus latency. Instead, persistent active infection drove virus-specific CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells toward functional exhaustion, a phenotype typically seen in chronic viral infections. Mechanistically, MCT1 deficiency sequentially impaired lactic acid efflux from activated CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, caused an intracellular acidification inhibiting glycolysis, disrupted nucleotide synthesis in the upstream pentose phosphate pathway, and halted cell proliferation which, ultimately, promoted functional CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell exhaustion instead of memory development. Taken together, our data demonstrate that MCT1 expression is mandatory for inducing T cell memory and controlling viral infection by CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2306763121","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T15:03:07Z","timestamp":1710774187000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8\n                    <sup>+<\/sup>\n                    T cell memory development"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4693-4565","authenticated-orcid":false,"given":"Stefania","family":"D\u2019Aria","sequence":"first","affiliation":[{"name":"Institute for Medical Immunology, Faculty of Medicine, Universit\u00e9 libre de Bruxelles, 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K.","family":"Dadhich","sequence":"additional","affiliation":[{"name":"Pole of Pharmacology, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 catholique de Louvain, Brussels 1200, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Freni\u00e8re","sequence":"additional","affiliation":[{"name":"Institute for Medical Immunology, Faculty of Medicine, Universit\u00e9 libre de Bruxelles, Gosselies 6041, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1020","authenticated-orcid":false,"given":"Fabienne","family":"Andris","sequence":"additional","affiliation":[{"name":"Immunobiology Laboratory, Faculty of Sciences, Universit\u00e9 libre de Bruxelles, Gosselies 6041, 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