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An interplay between disseminated tumor cells and heterogeneous bone resident cells in the metastatic niche initiates this process.\n                    <jats:italic>Melanoma differentiation associated gene-9<\/jats:italic>\n                    (\n                    <jats:italic>mda-9\/Syntenin\/syndecan binding protein<\/jats:italic>\n                    ) is a prometastatic gene expressed in multiple organs, including bone marrow\u2013derived mesenchymal stromal cells (BM-MSCs), under both physiological and pathological conditions. We demonstrate that PDGF-AA secreted by tumor cells induces CXCL5 expression in BM-MSCs by suppressing MDA-9-dependent YAP\/MST signaling. CXCL5-derived tumor cell proliferation and immune suppression are consequences of the MDA-9\/CXCL5 signaling axis, promoting PC disease progression.\n                    <jats:italic>mda-9<\/jats:italic>\n                    knockout tumor cells express less PDGF-AA and do not develop bone metastases. Our data document a previously undefined role of MDA-9\/Syntenin in the tumor and microenvironment in regulating PC bone metastasis. This study provides a framework for translational strategies to ameliorate health complications and morbidity associated with advanced PC.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2307094120","type":"journal-article","created":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T13:44:08Z","timestamp":1699019048000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":15,"title":["MDA-9\/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis"],"prefix":"10.1073","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8939-0636","authenticated-orcid":false,"given":"Santanu","family":"Maji","sequence":"first","affiliation":[{"name":"Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA 23298"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjan 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