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The UVR induces electrical, chemical, and biological signals to be sent to the brain, endocrine and immune systems, as well as other central organs, which in concert regulate body homeostasis. To achieve its central homeostatic goal, the UVR-induced signals are precisely computed locally with transmission through nerves or humoral signals release into the circulation to activate and\/or modulate coordinating central centers or organs. Such modulatory effects will be dependent on UVA and UVB wavelengths. This leads to immunosuppression, the activation of brain and endocrine coordinating centers, and the modification of different organ functions. Therefore, it is imperative to understand the underlying mechanisms of UVR electromagnetic energy penetration deep into the body, with its impact on the brain and internal organs. Photo-neuro-immuno-endocrinology can offer novel therapeutic approaches in addiction and mood disorders; autoimmune, neurodegenerative, and chronic pain-generating disorders; or pathologies involving endocrine, cardiovascular, gastrointestinal, or reproductive systems.<\/jats:p>","DOI":"10.1073\/pnas.2308374121","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T13:54:41Z","timestamp":1710510881000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":160,"title":["Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-1118","authenticated-orcid":false,"given":"Radomir M.","family":"Slominski","sequence":"first","affiliation":[{"name":"Departments of Genetics, the University of Alabama at Birmingham, Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8829-7504","authenticated-orcid":false,"given":"Jake Y.","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics and Data Science, the University of Alabama at Birmingham, Birmingham, AL 35294"},{"name":"Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7775-9988","authenticated-orcid":false,"given":"Chander","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the University of Alabama at Birmingham, Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-3995","authenticated-orcid":false,"given":"Andrzej T.","family":"Slominski","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL 35294"},{"name":"Department of Dermatology, the University of Alabama at Birmingham, Birmingham, AL 35294"},{"name":"Veteran Administration Medical Center, Birmingham, AL 35294"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,3,15]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03230"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.4161\/derm.24494"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms140612222"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-72655-7"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0235948"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14902"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2007.00226.x"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1982.tb04362.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012809"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-19683-6_1"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/42\/5\/004"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1006\/icar.1999.6167"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.815"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-3-12"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0020"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1088\/0034-4885\/74\/6\/066701"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.10338"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2010.01202.x"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-017-2617-7"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1994.tb05065.x"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/JR9520000338"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/092986712803414321"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253735"},{"key":"e_1_3_4_24_2","volume-title":"Feldman and Pike\u2019s Vitamin D","author":"Hewison M.","year":"2024","unstructured":"M. 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