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Finally, free T3 among older adults is associated with labor both in terms of unemployment and hours worked. Physiologic TSH\/T4 explain only 1.7% of T3 variation, and neither are appreciably correlated to socio-economic outcomes. Taken together, our data suggest an unappreciated complexity of the HPT-axis signaling cascade broadly such that TSH and T4 may not be accurate surrogates of free T3. 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