{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:44:55Z","timestamp":1791240295137,"version":"4.1.0"},"reference-count":70,"publisher":"National Academy of Sciences","issue":"42","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["DP200100344"],"award-info":[{"award-number":["DP200100344"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000925","name":"John Templeton Foundation","doi-asserted-by":"publisher","award":["54860"],"award-info":[{"award-number":["54860"]}],"id":[{"id":"10.13039\/100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:p>\n                    In the first live-bearing mammals, pregnancy was likely short and ended with a brief period of inflammatory maternal\u2013fetal interaction. This mode of reproduction has been retained in many marsupials. While inflammation is key to successful implantation in eutherians, a key innovation in eutherians is the ability to switch off this inflammation after it has been initiated. This extended period, in which inflammation is suppressed, likely allowed for an extended period of placentation. Extended placentation has evolved independently in one lineage of marsupials, the macropodids (wallabies and kangaroos), with placentation lasting beyond the 2 to 4 d seen in other marsupial taxa, which allows us to investigate the role of inflammation response after attachment in the extension of placentation in mammals. By comparing gene expression changes at attachment in three marsupial species, the tammar wallaby, opossum, and fat-tailed dunnart, we show that inflammatory attachment is an ancestral feature of marsupial implantation. In contrast to eutherians, where attachment-related (quasi-) inflammatory reaction is even involved in epitheliochorial placentation (e.g., pig), this study found no evidence of a distinct attachment-related reaction in wallabies. Instead, only a small number of inflammatory genes are expressed at distinct points of gestation, including\n                    <jats:italic>IL6<\/jats:italic>\n                    before attachment,\n                    <jats:italic>LIF<\/jats:italic>\n                    throughout placentation, and prostaglandins before birth. During parturition, a more distinct inflammatory reaction is detectable, likely involved in precipitating the parturition cascade similar to eutherians. We suggest that in wallaby, extended gestation became possible by avoiding an inflammatory attachment reaction, which is a different strategy than seen in eutherians.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2310047121","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:10:41Z","timestamp":1728389441000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":10,"title":["The extension of mammalian pregnancy required taming inflammation: Independent evolution of extended placentation in the tammar wallaby"],"prefix":"10.1073","volume":"121","author":[{"given":"Jessica S.","family":"Dudley","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-0436","authenticated-orcid":false,"given":"Marilyn B.","family":"Renfree","sequence":"additional","affiliation":[{"name":"School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-002X","authenticated-orcid":false,"given":"G\u00fcnter P.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520"},{"name":"Yale Systems Biology Institute, Yale University, West Haven, CT 06520"},{"name":"Department of Evolutionary Biology, University of Vienna, Vienna A-1030, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9703-7800","authenticated-orcid":false,"given":"Oliver W.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, School of Natural Sciences, Faculty of Science and Engineering, Macquarie University, NSW 2109, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,10,8]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1701129114"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2017.08.004"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12266"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1897"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251816"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05938.x"},{"key":"e_1_3_4_7_2","first-page":"36","article-title":"Pregnancy reconceived","volume":"116","author":"Mor G.","year":"2007","unstructured":"G. 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