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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,2,13]]},"abstract":"<jats:p>\n                    Bats are associated with the circulation of most mammalian filoviruses (FiVs), with pathogenic ones frequently causing deadly hemorrhagic fevers in Africa. Divergent FiVs have been uncovered in Chinese bats, raising concerns about their threat to public health. Here, we describe a long-term surveillance to track bat FiVs at orchards, eventually resulting in the identification and isolation of a FiV, Dehong virus (DEHV), from\n                    <jats:italic>Rousettus leschenaultii<\/jats:italic>\n                    bats. DEHV has a typical filovirus-like morphology with a wide spectrum of cell tropism. Its entry into cells depends on the engagement of Niemann-Pick C1, and its replication is inhibited by remdesivir. DEHV has the largest genome size of filoviruses, with phylogenetic analysis placing it between the genera\n                    <jats:italic>Dianlovirus<\/jats:italic>\n                    and\n                    <jats:italic>Orthomarburgvirus<\/jats:italic>\n                    , suggesting its classification as the prototype of a new genus within the family\n                    <jats:italic>Filoviridae<\/jats:italic>\n                    . The continuous detection of viral RNA in the serological survey, together with the wide host distribution, has revealed that the region covering southern Yunnan, China, and bordering areas is a natural circulation sphere for bat FiVs. These emphasize the need for a better understanding of the pathogenicity and potential risk of FiVs in the region.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2313789121","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T13:42:57Z","timestamp":1707486177000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Isolation, characterization, and circulation sphere of a filovirus in fruit bats"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7587-152X","authenticated-orcid":false,"given":"Biao","family":"He","sequence":"first","affiliation":[{"name":"Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, Jilin Province 130122, 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