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KCTD10 mediated the ubiquitination-dependent degradation of KCTD13 and KCTD10 ablation resulted in a considerable increase of KCTD13 expression in the developing cortex. KCTD13 overexpression in neuronal progenitors led to reduced proliferation and abnormal cell distribution, mirroring KCTD10 deficiency. Notably, mice with brain-specific\n                    <jats:italic>Kctd10<\/jats:italic>\n                    knockout exhibited obvious motor deficits. This study uncovers the physiological function of KCTD10 and provides unique insights into the pathogenesis of neurodevelopmental disorders.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2315707121","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T13:54:17Z","timestamp":1710510857000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":12,"title":["KCTD10 regulates brain development by destabilizing brain disorder\u2013associated protein KCTD13"],"prefix":"10.1073","volume":"121","author":[{"given":"Jianbo","family":"Cheng","sequence":"first","affiliation":[{"name":"Center for Medical Genetics, Hunan Key Laboratory of Medical Genetics, Key Lab of Rare Pediatric Diseases of Ministry of Education, School of Life Sciences, Central South University, Changsha, Hunan 410078, 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