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Purified amino acids were sufficient for this effect, which was a consequence of accelerated eosinophil turnover within the tissue microenvironment and was not due to altered development in the bone marrow. Our study provides insight into the process of eosinophil adaptation to the SI, highlighting its reliance on nutrient-derived signals.<\/jats:p>","DOI":"10.1073\/pnas.2316446121","type":"journal-article","created":{"date-parts":[[2024,1,25]],"date-time":"2024-01-25T13:28:55Z","timestamp":1706189335000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":24,"title":["Nutrient-derived signals regulate eosinophil adaptation to the small intestine"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-4722","authenticated-orcid":false,"given":"Vassily","family":"I. 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