{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:45:40Z","timestamp":1792251940931,"version":"4.4.0"},"reference-count":69,"publisher":"National Academy of Sciences","issue":"12","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,3,19]]},"abstract":"<jats:p>\n                    Endogenous retroviruses (ERVs) are frequently reactivated in mammalian placenta. It has been proposed that ERVs contribute to shaping the gene regulatory network of mammalian trophoblasts, dominantly acting as species- and placental-specific enhancers. However, whether and how ERVs control human trophoblast development through alternative pathways remains poorly understood. Besides the well-recognized function of human endogenous retrovirus-H (HERVH) in maintaining pluripotency of early human epiblast, here we present a unique role of HERVH on trophoblast lineage development. We found that the LTR7C\/HERVH subfamily exhibits an accessible chromatin state in the human trophoblast lineage. Particularly, the LTR7C\/HERVH-derived\n                    <jats:italic>Urothelial Cancer Associated 1<\/jats:italic>\n                    (\n                    <jats:italic>UCA1<\/jats:italic>\n                    ), a primate-specific long non-coding RNA (lncRNA), is transcribed in human trophoblasts and promotes the proliferation of human trophoblast stem cells (hTSCs), whereas its ectopic expression compromises human trophoblast syncytialization coinciding with increased interferon signaling pathway. Importantly,\n                    <jats:italic>UCA1<\/jats:italic>\n                    upregulation is detectable in placental samples from early-onset preeclampsia (EO-PE) patients and the transcriptome of EO-PE placenta exhibits considerable similarities to that of the syncytiotrophoblasts differentiated from\n                    <jats:italic>UCA1<\/jats:italic>\n                    -overexpressing hTSCs, supporting up-regulated\n                    <jats:italic>UCA1<\/jats:italic>\n                    as a potential biomarker of this disease. Altogether, our data shed light on the versatile regulatory role of HERVH in early human development and provide a unique mechanism whereby ERVs exert a function in human placentation and placental syndromes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2318176121","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T13:50:25Z","timestamp":1710424225000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":26,"title":["Endogenous retrovirus HERVH-derived lncRNA\n                    <i>UCA1<\/i>\n                    controls human trophoblast development"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2042-4535","authenticated-orcid":false,"given":"Xuhui","family":"Kong","sequence":"first","affiliation":[{"name":"Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0196-1965","authenticated-orcid":false,"given":"Ruiqi","family":"Li","sequence":"additional","affiliation":[{"name":"Reproductive and Genetic Hospital of Kapok, Hainan 571400, China"},{"name":"Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China"},{"name":"The First People\u2019s Hospital of Kashgar, Kashgar 844000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongyan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7027-0298","authenticated-orcid":false,"given":"Jichang","family":"Wang","sequence":"additional","affiliation":[{"name":"Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanbo","family":"Sun","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Systems Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6203-0032","authenticated-orcid":false,"given":"Yuliang","family":"Qu","sequence":"additional","affiliation":[{"name":"Advanced Medical Technology Center, The First Affiliated Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Key Laboratory for Stem Cells and Tissue Engineering, Sun Yat-sen University, Ministry of Education, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,3,14]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41371-023-00802-4"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0372-6"},{"key":"e_1_3_4_3_2","first-page":"20230191","article-title":"The human placenta: New perspectives on its formation and function during early pregnancy","volume":"290","author":"Burton G. 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Kong Endogenous retrovirus HERVH-derived lncRNA UCA1 controls human trophoblast development. The National Genomics Data Center. https:\/\/ngdc.cncb.ac.cn\/. 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