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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,5,7]]},"abstract":"<jats:p>\n                    Eosinophil recruitment is a pathological hallmark of many allergic and helminthic diseases. Here, we investigated chemokine receptor CCR3-induced eosinophil recruitment in sialyltransferase\n                    <jats:italic>\n                      St3gal4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. We found a marked decrease in eosinophil extravasation into CCL11-stimulated cremaster muscles and into the inflamed peritoneal cavity of\n                    <jats:italic>\n                      St3gal4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice. Ex vivo flow chamber assays uncovered reduced adhesion of\n                    <jats:italic>St3gal4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    compared to wild type eosinophils. Using flow cytometry, we show reduced binding of CCL11 to\n                    <jats:italic>\n                      St3gal4\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    eosinophils. Further, we noted reduced binding of CCL11 to its chemokine receptor CCR3 isolated from\n                    <jats:italic>St3gal4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    eosinophils. This was accompanied by almost absent CCR3 internalization of CCL11-stimulated\n                    <jats:italic>St3gal4<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    eosinophils. Applying an ovalbumin-induced allergic airway disease model, we found a dramatic reduction in eosinophil numbers in bronchoalveolar lavage fluid following intratracheal challenge with ovalbumin in\n                    <jats:italic>St3gal4<\/jats:italic>\n                    -deficient mice. Finally, we also investigated tissue-resident eosinophils under homeostatic conditions and found reduced resident eosinophil numbers in the thymus and adipose tissue in the absence of ST3Gal-IV. Taken together, our results demonstrate an important role of ST3Gal-IV in CCR3-induced eosinophil recruitment in vivo rendering this enzyme an attractive target in reducing unwanted eosinophil infiltration in various disorders including allergic diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2319057121","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T13:38:01Z","timestamp":1714484281000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["CCR3-dependent eosinophil recruitment is regulated by sialyltransferase ST3Gal-IV"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-7528","authenticated-orcid":false,"given":"Roland","family":"Immler","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Physiology and Pathophysiology, Walter Brendel Center of Experimental Medicine, Ludwig-Maximilians-Universit\u00e4t 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