{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:26:23Z","timestamp":1789154783163,"version":"build-2803163510"},"reference-count":63,"publisher":"National Academy of Sciences","issue":"21","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.22036005"],"award-info":[{"award-number":["No.22036005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U23A20103"],"award-info":[{"award-number":["U23A20103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key R&D Program of China","award":["2023YFC3708305"],"award-info":[{"award-number":["2023YFC3708305"]}]},{"name":"the Special Fund for Scientific and Technological Innovation Talent Teams of Shanxi Province","award":["No.202204051002024"],"award-info":[{"award-number":["No.202204051002024"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,5,21]]},"abstract":"<jats:p>\n                    As a global problem, fine particulate matter (PM\n                    <jats:sub>2.5<\/jats:sub>\n                    ) really needs local fixes. Considering the increasing epidemiological relevance to anxiety and depression but inconsistent toxicological results, the most important question is to clarify whether and how PM\n                    <jats:sub>2.5<\/jats:sub>\n                    causally contributes to these mental disorders and which components are the most dangerous for crucial mitigation in a particular place. In the present study, we chronically subjected male mice to a real-world PM\n                    <jats:sub>2.5<\/jats:sub>\n                    exposure system throughout the winter heating period in a coal combustion area and revealed that PM\n                    <jats:sub>2.5<\/jats:sub>\n                    caused anxiety and depression-like behaviors in adults such as restricted activity, diminished exploratory interest, enhanced repetitive stereotypy, and elevated acquired immobility, through behavioral tests including open field, elevated plus maze, marble-burying, and forced swimming tests. Importantly, we found that dopamine signaling was perturbed using mRNA transcriptional profile and bioinformatics analysis, with Drd1 as a potential target. Subsequently, we developed the\n                    <jats:italic>Drd1<\/jats:italic>\n                    expression-directed multifraction isolating and nontarget identifying framework and identified a total of 209 compounds in PM\n                    <jats:sub>2.5<\/jats:sub>\n                    organic extracts capable of reducing\n                    <jats:italic>Drd1<\/jats:italic>\n                    expression. Furthermore, by applying hierarchical characteristic fragment analysis and molecular docking and dynamics simulation, we clarified that phenyl-containing compounds competitively bound to DRD1 and interfered with dopamine signaling, thereby contributing to mental disorders. Taken together, this work provides experimental evidence for researchers and clinicians to identify hazardous factors in PM\n                    <jats:sub>2.5<\/jats:sub>\n                    and prevent adverse health outcomes and for local governments and municipalities to control source emissions for diminishing specific disease burdens.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2319595121","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:01:27Z","timestamp":1715612487000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":42,"title":["PM\n                    <sub>2.5<\/sub>\n                    exposure contributes to anxiety and depression-like behaviors via phenyl-containing compounds interfering with dopamine receptor"],"prefix":"10.1073","volume":"121","author":[{"given":"Shaoyang","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-1305","authenticated-orcid":false,"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Environment Science, College of Environment and Resource, Research Center of Environment and Health, Shanxi University, Taiyuan, Shanxi 030006, People\u2019s Republic of China"},{"name":"Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, Xuzhou Medical University, Xuzhou, Jiangsu 221004, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Environment Engineering, College of Quality and Safety Engineering, China Jiliang University, Hangzhou, Zhejiang 310018, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjian","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Environment Engineering, College of Quality and Safety Engineering, China Jiliang University, Hangzhou, Zhejiang 310018, People\u2019s Republic of China"},{"name":"Institute of Environmental and Health Sciences, China Jiliang University, Hangzhou, Zhejiang 310018, People\u2019s Republic of 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