{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:29:58Z","timestamp":1791228598792,"version":"4.1.0"},"reference-count":101,"publisher":"National Academy of Sciences","issue":"24","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,6,11]]},"abstract":"<jats:p>\n                    <jats:italic>Cannabis sativa<\/jats:italic>\n                    is known for its therapeutic benefit in various diseases including pain relief by targeting cannabinoid receptors. The primary component of cannabis, \u03949-tetrahydrocannabinol (THC), and other agonists engage the orthosteric site of CB1, activating both Gi and \u03b2-arrestin signaling pathways. The activation of diverse pathways could result in on-target side effects and cannabis addiction, which may hinder therapeutic potential. A significant challenge in pharmacology is the design of a ligand that can modulate specific signaling of CB1. By leveraging insights from the structure\u2013function selectivity relationship (SFSR), we have identified Gi signaling\u2013biased agonist-allosteric modulators (ago-BAMs). Further, two cryoelectron microscopy (cryo-EM) structures reveal the binding mode of ago-BAM at the extrahelical allosteric site of CB1. Combining mutagenesis and pharmacological studies, we elucidated the detailed mechanism of ago-BAM-mediated biased signaling. Notably, ago-BAM\n                    <jats:bold>CB-05<\/jats:bold>\n                    demonstrated analgesic efficacy with fewer side effects, minimal drug toxicity and no cannabis addiction in mouse pain models. In summary, our finding not only suggests that ago-BAMs of CB1 provide a potential nonopioid strategy for pain management but also sheds light on BAM identification for GPCRs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2321532121","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:05:07Z","timestamp":1717427107000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":33,"title":["Structure-based identification of a G protein\u2013biased allosteric modulator of cannabinoid receptor CB1"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9823-8321","authenticated-orcid":false,"given":"Siyuan","family":"Shen","sequence":"first","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2888-6099","authenticated-orcid":false,"given":"Guifeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9800-7766","authenticated-orcid":false,"given":"Yangli","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8273-1338","authenticated-orcid":false,"given":"Chang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Tian","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqian","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nihong","family":"Guo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2695-3024","authenticated-orcid":false,"given":"Anjie","family":"Xia","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingming","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengyong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7204-801X","authenticated-orcid":false,"given":"Zhenhua","family":"Shao","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China"},{"name":"Frontiers Medical Center, Tianfu Jincheng Laboratory, Chengdu 610212, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.198"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.001055"},{"key":"e_1_3_4_3_2","article-title":"Cannabinoid receptors and their relationship with chronic pain: A narrative review","volume":"12","author":"Anthony A. T.","year":"2020","unstructured":"A. T. Anthony, S. Rahmat, P. Sangle, O. Sandhu, S. Khan, Cannabinoid receptors and their relationship with chronic pain: A narrative review. Cureus 12, e10436 (2020).","journal-title":"Cureus"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.816747"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104822"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2019.12.006"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020373"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4334"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00444-w"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-020-00873-9"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03658"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(02)00154-8"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06751.x"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.06.015"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph3082661"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010891"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-41199-1_22"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1431"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.027"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1507771"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1039\/C8MD00595H"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152709789824660"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.2174\/187152712801661310"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12492"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-23-08932.2000"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1484-0"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/09540260902782752"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702228"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.09.042"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.04.005"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-018-0993-7"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01038-y"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0387-2"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.148"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.06.032"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00252"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00040"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.12.005"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02381-w"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-46450-2_7"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2020.115727"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.9b00069"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","unstructured":"B. M. Ford Characterization of structurally novel G protein biased CB(1) agonists: Implications for drug development. Pharmacol. Res. 125 161\u2013177 (2017).","DOI":"10.1016\/j.phrs.2017.08.008"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","unstructured":"P.A.-O.X. Kolb Community guidelines for GPCR ligand bias: IUPHAR review 32. Br. J. Pharmacol. 179 3651\u20133674 (2022).","DOI":"10.1111\/bph.15811"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36673-z"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","unstructured":"T. Kenakin A simple method for quantifying functional selectivity and agonist bias. ACS Chem. Neurosci. 3 193\u2013203 (2012).","DOI":"10.1021\/cn200111m"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204189"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.135"},{"key":"e_1_3_4_49_2","first-page":"293","article-title":"Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits","volume":"50","author":"Standifer K. M.","year":"1996","unstructured":"K. M. Standifer, G. C. Rossi, G. W. Pasternak, Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein alpha subunits. Mol. Pharmacol. 50, 293\u2013298 (1996).","journal-title":"Mol. Pharmacol."},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180194597"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02387-8"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2003.11.024"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.91"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-020-0535-8"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature23652"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3417"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.028"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00482-0"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature18636"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00310"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.08.006"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2419-1"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1953-1"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00210-X"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(95)00191-8"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.06.015"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-050214-013454"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000006266"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.037"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05588-y"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0219-7"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19112"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aay9813"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00156-w"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.053"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.606656"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature20613"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi400842k"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200421927"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.037"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.197780"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm5006463"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1137604"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.07.030"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01625-y"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.026"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.09.041"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01208-y"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7065"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03897-2"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01208-y"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-021-00566-x"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-26"},{"key":"e_1_3_4_95_2","doi-asserted-by":"publisher","DOI":"10.1038\/32897"},{"key":"e_1_3_4_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(00)00276-1"},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.abn7065"},{"key":"e_1_3_4_98_2","article-title":"8IKH, Cryo-EM structure of CB1-Gi complex","author":"Shen S.","unstructured":"S. Shen , 8IKH, Cryo-EM structure of CB1-Gi complex. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/unreleased\/8IKH. Deposited 28 February 2023.","journal-title":"Protein"},{"key":"e_1_3_4_99_2","article-title":"EMD-35512, Cryo-EM structure of CB1-Gi complex","author":"Shen S.","unstructured":"S. Shen , EMD-35512, Cryo-EM structure of CB1-Gi complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-35512. Deposited 28 February 2023.","journal-title":"Electron Microscopy"},{"key":"e_1_3_4_100_2","article-title":"8IKG, Cryo-EM structure of CB1-Gi complex","author":"Shen S.","unstructured":"S. Shen , 8IKG, Cryo-EM structure of CB1-Gi complex. Protein Data Bank. https:\/\/www.rcsb.org\/structure\/unreleased\/8IKG. Deposited 28 February 2023.","journal-title":"Protein"},{"key":"e_1_3_4_101_2","article-title":"EMD-35511, Cryo-EM structure of CB1-Gi complex","author":"Shen S.","unstructured":"S. Shen , EMD-35511, Cryo-EM structure of CB1-Gi complex. Electron Microscopy Data Bank. https:\/\/www.ebi.ac.uk\/emdb\/EMD-35511. Deposited 28 February 2023.","journal-title":"Electron Microscopy"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2321532121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:07:16Z","timestamp":1717427236000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/10.1073\/pnas.2321532121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":101,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2024,6,11]]}},"alternative-id":["10.1073\/pnas.2321532121"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2321532121","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]},"assertion":[{"value":"2023-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2321532121"}}