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To enable efficient delivery of PSs, a charge-conversional and redox-responsive block copolymer POEGMA-\n                    <jats:italic>b<\/jats:italic>\n                    -(PAEMA\/DMMA-\n                    <jats:italic>co<\/jats:italic>\n                    -BMA) (PB) was designed to construct a protein-binding photodynamic nanoinhibitor (FBC@PB), which not only prolongs blood circulation and enhances cellular uptake but also releases FBC on demand in tumor microenvironment (TME). Meanwhile, PDT-induced destruction of cancer cells could produce tumor-associated antigens which were capable to trigger robust antitumor immune responses, facilitating the eradication of residual cancer cells. A series of experiments in vitro and in vivo demonstrated that this multifunctional nanoinhibitor provides a promising strategy to extend photodynamic immunotherapy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2321545121","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T12:46:52Z","timestamp":1715086012000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["A TME-enlightened protein-binding photodynamic nanoinhibitor for highly effective oncology treatment"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1717-597X","authenticated-orcid":false,"given":"Zepeng","family":"Cui","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1437-5420","authenticated-orcid":false,"given":"Jiahao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-4522","authenticated-orcid":false,"given":"Jia","family":"Tian","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"},{"name":"School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,5,7]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201600417"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202212210"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216361"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1039\/C7TB02381B"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2019.123961"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2021.101363"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202307"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.8b01072"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.2c13189"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.1c00381"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201804324"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201900791"},{"key":"e_1_3_4_13_2","first-page":"42","article-title":"Engineering naphthalimide-cyanine integrated near-infrared dye into ROS-responsive nanohybrids for tumor PDT\/PTT\/chemotherapy","volume":"14","author":"Jin T.","year":"2022","unstructured":"T. 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