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In this study, we demonstrate that the loss of function of\n                    <jats:italic>CAPE<\/jats:italic>\n                    in\n                    <jats:italic>M. polymorpha<\/jats:italic>\n                    led to male infertility due to impaired sperm flagellar motility. We also found that two genes encoding the regulatory subunits of cAMP-dependent protein kinase (PKA-R) were also involved in sperm motility. Based on these findings, it is evident that CAPE and PKA-Rs act as a cAMP signaling module that regulates sperm motility in\n                    <jats:italic>M. polymorpha<\/jats:italic>\n                    . Therefore, our results have shed light on the function of cAMP signaling and sperm motility regulators in land plants. This study suggests that cAMP signaling plays a common role in plant and animal sperm motility.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2322211121","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T13:38:10Z","timestamp":1712669890000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["The cAMP signaling module regulates sperm motility in the liverwort\n                    <i>Marchantia polymorpha<\/i>"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6893-7389","authenticated-orcid":false,"given":"Chiaki","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Graduate School of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of 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