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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2025,8,5]]},"abstract":"<jats:p>\n                    Weakening of synaptic transmission at the\n                    <jats:italic toggle=\"yes\">Drosophila<\/jats:italic>\n                    larval neuromuscular junction triggers two forms of homeostatic compensation, one that increases the probability of glutamate release per action potential (\n                    <jats:italic toggle=\"yes\">\n                      P\n                      <jats:sub>r<\/jats:sub>\n                    <\/jats:italic>\n                    ) and another that increases motoneuron (MN) activity. We investigated the molecular changes in MNs that underlie the increase in MN activity. RNA sequencing (RNA-seq) analysis on MNs whose glutamate release is weakened by knockdown of components of the MN transmitter release machinery reveals a reduction in expression of a group of genes that encode potassium channels and their positive modulators. These results identify a mechanism of compensation for weakened synaptic transmission by MNs, which engages a transcriptional program in those cells to increase firing and, thereby, ensure sufficient locomotory drive.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2322714122","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T17:38:00Z","timestamp":1753810680000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":1,"title":["Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability"],"prefix":"10.1073","volume":"122","author":[{"given":"Caroline A.","family":"Cypranowska","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Feldthouse","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Gi","family":"Choi","sequence":"additional","affiliation":[{"name":"Functional Genomics Laboratory, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariya","family":"Bakshinska","sequence":"additional","affiliation":[{"name":"Helen Wills Neuroscience Institute, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary L.","family":"Newman","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4775-9359","authenticated-orcid":false,"given":"Ehud Y.","family":"Isacoff","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, University of California Berkeley","place":["Berkeley"]},{"name":"Helen Wills Neuroscience Institute, University of California Berkeley","place":["Berkeley"]},{"name":"Department of Neuroscience, University of California Berkeley","place":["Berkeley"]},{"name":"Weill-Neurohub East, University of California Berkeley","place":["Berkeley"]},{"name":"Molecular Biophysics and Integrated BioImaging Division, Lawrence Berkeley National Laboratory","place":["Berkeley"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1949"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a005736"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.09.044"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021014-071740"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.028"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2019.09.036"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.110105"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80415-8"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","unstructured":"C. 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