{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:23:53Z","timestamp":1792268633055,"version":"4.4.0"},"reference-count":62,"publisher":"National Academy of Sciences","issue":"36","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20POST3521111"],"award-info":[{"award-number":["20POST3521111"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"Human Frontier Science Program","doi-asserted-by":"publisher","award":["LT001449\/2017\u2010L"],"award-info":[{"award-number":["LT001449\/2017\u2010L"]}],"id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>\n                    Constricting pythons, known for their ability to consume infrequent, massive meals, exhibit rapid and reversible cardiac hypertrophy following feeding. Our primary goal was to investigate how python hearts achieve this adaptive response after feeding. Isolated myofibrils increased force after feeding without changes in sarcomere ultrastructure and without increasing energy cost. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transients were prolonged after feeding with no changes in myofibril Ca\n                    <jats:sup>2+<\/jats:sup>\n                    sensitivity. Feeding reduced titin-based tension, resulting in decreased cardiac tissue stiffness. Feeding also reduced the activity of sirtuins, a metabolically linked class of histone deacetylases, and increased chromatin accessibility. Transcription factor enrichment analysis on transposase-accessible chromatin with sequencing revealed the prominent role of transcription factors Yin Yang1 and NRF1 in postfeeding cardiac adaptation. Gene expression also changed with the enrichment of translation and metabolism. Finally, metabolomics analysis and adenosine triphosphate production demonstrated that cardiac adaptation after feeding not only increased energy demand but also energy production. These findings have broad implications for our understanding of cardiac adaptation across species and hold promise for the development of innovative approaches to address cardiovascular diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2322726121","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T15:06:41Z","timestamp":1724080001000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":9,"title":["Postprandial cardiac hypertrophy is sustained by mechanics, epigenetic, and metabolic reprogramming in pythons"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-2726","authenticated-orcid":false,"given":"Claudia","family":"Crocini","sequence":"first","affiliation":[{"name":"Max Rubner Center for Cardiovascular Metabolic Renal Research (MRC), Deutsches Herzzentrum der Charit\u00e9 (DHZC), Charit\u00e9 University Medicine Berlin, Berlin 10115, Germany"},{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"},{"name":"Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9885-7026","authenticated-orcid":false,"given":"Kathleen C.","family":"Woulfe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher D.","family":"Ozeroff","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"},{"name":"Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Perni","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-6508","authenticated-orcid":false,"given":"Joseph","family":"Cardiello","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cierra J.","family":"Walker","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-344X","authenticated-orcid":false,"given":"Cortney E.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-5691","authenticated-orcid":false,"given":"Kristi","family":"Anseth","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7490-0165","authenticated-orcid":false,"given":"Mary Ann","family":"Allen","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-4810","authenticated-orcid":false,"given":"Leslie A.","family":"Leinwand","sequence":"additional","affiliation":[{"name":"BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303"},{"name":"Department of Molecular, Cellular and Developmental Biology, University of Colorado Boulder, Boulder, CO 80303"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/27131"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00661.2011"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.198.6.1313"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(99)00127-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.034058"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.203.16.2447"},{"key":"e_1_3_4_7_2","first-page":"3009","article-title":"Improved cardiac filling facilitates the postprandial elevation of stroke volume in Python regius","volume":"219","author":"Enok S.","year":"2016","unstructured":"S. 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