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We then investigated the effects of cardiac injury through a modified experimental autoimmune myocarditis mouse model and an ischemia\u2013reperfusion injury mouse model and determined that cardiac inflammation induces the recruitment of autoreactive MyHC T\n                    <jats:sub>RM<\/jats:sub>\n                    cells, which coexpress PD-1 and CD69. To investigate whether the recruited MyHC T\n                    <jats:sub>RM<\/jats:sub>\n                    cells could increase susceptibility to ICI-myocarditis, we developed a two-hit ICI-myocarditis mouse model where cardiac injury was induced, mice were allowed to recover, and then were treated with anti-PD-1 antibodies. We determined that mice who recover from cardiac injury are more susceptible to ICI-myocarditis development. We found that murine and human T\n                    <jats:sub>RM<\/jats:sub>\n                    cells share a similar location in the heart and aggregate along the perimyocardium. We phenotyped cells obtained from pericardial fluid from patients diagnosed with dilated cardiomyopathy and ischemic cardiomyopathy and established that pericardial T cells are predominantly CD69\n                    <jats:sup>+<\/jats:sup>\n                    T\n                    <jats:sub>RM<\/jats:sub>\n                    cells that up-regulate PD-1. Finally, we determined that human pericardial macrophages produce IL-15, which supports and maintains pericardial T\n                    <jats:sub>RM<\/jats:sub>\n                    cells.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2323052121","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T12:10:41Z","timestamp":1728389441000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Injury-induced myosin-specific tissue-resident memory T cells drive immune checkpoint inhibitor myocarditis"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2732-0077","authenticated-orcid":false,"given":"Hannah","family":"Kalinoski","sequence":"first","affiliation":[{"name":"W. 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