{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:45:41Z","timestamp":1791398741290,"version":"4.3.3"},"reference-count":48,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2003,11,25]]},"abstract":"<jats:p>\n                    The retinoic acid (RA) signal, produced locally from vitamin A by retinaldehyde dehydrogenase (Raldh) and transduced by the nuclear receptors for retinoids (RA receptor and 9-\n                    <jats:italic>cis<\/jats:italic>\n                    -RA receptor), is indispensable for ontogenesis and homeostasis of numerous tissues. We demonstrate that\n                    <jats:italic>Raldh3<\/jats:italic>\n                    knockout in mouse suppresses RA synthesis and causes malformations restricted to ocular and nasal regions, which are similar to those observed in vitamin A-deficient fetuses and\/or in retinoid receptor mutants.\n                    <jats:italic>Raldh3<\/jats:italic>\n                    knockout notably causes choanal atresia (CA), which is responsible for respiratory distress and death of\n                    <jats:italic>Raldh3<\/jats:italic>\n                    -null mutants at birth. CA is due to persistence of nasal fins, whose rupture normally allows the communication between nasal and oral cavities. This malformation, which is similar to isolated congenital CA in humans and may result from impaired RA-controlled down-regulation of\n                    <jats:italic>Fgf8<\/jats:italic>\n                    expression in nasal fins, can be prevented by a simple maternal treatment with RA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2336223100","type":"journal-article","created":{"date-parts":[[2003,11,25]],"date-time":"2003-11-25T15:59:06Z","timestamp":1069775946000},"page":"14036-14041","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":291,"title":["A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment"],"prefix":"10.1073","volume":"100","author":[{"given":"Val\u00e9rie","family":"Dup\u00e9","sequence":"first","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Matt","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Garnier","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Chambon","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mark","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert B.","family":"Ghyselinck","sequence":"additional","affiliation":[{"name":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique\/Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale\/Universit\u00e9 Louis Pasteur, Coll\u00e8ge de France, BP10142, 67404 Illkirch Cedex, Communaut\u00e9 Urbaine de Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2003,11,17]]},"reference":[{"key":"e_1_3_2_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000920202"},{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01497.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(08)60722-9"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(96)00653-3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00561-5"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M211417200"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.9.8801176"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90202-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1351\/pac200375111709"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200211117"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/7788"},{"key":"e_1_3_2_12_2","first-page":"75","volume":"127","year":"2000","unstructured":"Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. & Doll\u00e9, P. (2000) Development (Cambridge, U.K.) 127, 75\u201385.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_13_2","first-page":"1019","volume":"128","year":"2001","unstructured":"Niederreither, K., Vermot, J., Messaddeq, N., Schuhbaur, B., Chambon, P. & Doll\u00e9, P. (2001) Development (Cambridge, U.K.) 128, 1019\u20131031.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_14_2","first-page":"3111","volume":"124","year":"1997","unstructured":"Dickman, E. D., Thaller, C. & Smith, S. M. (1997) Development (Cambridge, U.K.) 124, 3111\u20133121.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9635"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.9754"},{"key":"e_1_3_2_17_2","first-page":"2031","volume":"128","year":"2001","unstructured":"Wendling, O., Ghyselinck, N. B., Chambon, P. & Mark, M. (2001) Development (Cambridge, U.K.) 128, 2031\u20132038.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.8.1333"},{"key":"e_1_3_2_19_2","first-page":"2271","volume":"129","year":"2002","unstructured":"Mic, F. A., Haselbeck, R. J., Cuenca, A. E. & Duester, G. (2002) Development (Cambridge, U.K.) 129, 2271\u20132282.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252626599"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00352-X"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00434-2"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007376200"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(00)00450-0"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.13.4637-4648.2003"},{"key":"e_1_3_2_26_2","first-page":"3563","volume":"129","year":"2002","unstructured":"Niederreither, K., Vermot, J., Schuhbaur, B., Chambon, P. & Doll\u00e9, P. (2002) Development (Cambridge, U.K.) 129, 3563\u20133574.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_27_2","first-page":"399","volume":"124","year":"1997","unstructured":"Dup\u00e9, V., Davenne, M., Brocard, J., Doll\u00e9, P., Mark, M., Dierich, A., Chambon, P. & Rijli, F. M. (1997) Development (Cambridge, U.K.) 124, 399\u2013410.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_28_2","first-page":"425","volume":"41","year":"1997","unstructured":"Ghyselinck, N. B., Dup\u00e9, V., Dierich, A., Messaddeq, N., Garnier, J. M., Rochette-Egly, C., Chambon, P. & Mark, M. (1997) Int. J. Dev. Biol. 41, 425\u2013447.9240560","journal-title":"Int. J. Dev. Biol."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90274-7"},{"key":"e_1_3_2_30_2","first-page":"2723","volume":"120","year":"1994","unstructured":"Lohnes, D., Mark, M., Mendelsohn, C., Doll\u00e9, P., Dierich, A., Gorry, P., Gansmuller, A. & Chambon, P. (1994) Development (Cambridge, U.K.) 120, 2723\u20132748.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_31_2","first-page":"313","volume":"124","year":"1997","unstructured":"Kastner, P., Mark, M., Ghyselinck, N., Krezel, W., Dup\u00e9, V., Grondona, J. M. & Chambon, P. (1997) Development (Cambridge, U.K.) 124, 313\u2013326.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_32_2","first-page":"4691","volume":"125","year":"1998","unstructured":"Mascrez, B., Mark, M., Dierich, A., Ghyselinck, N. B., Kastner, P. & Chambon, P. (1998) Development (Cambridge, U.K.) 125, 4691\u20134707.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_33_2","first-page":"2049","volume":"128","year":"2001","unstructured":"Mascrez, B., Mark, M., Krezel, W., Dup\u00e9, V., LeMeur, M., Ghyselinck, N. B. & Chambon, P. (2001) Development (Cambridge, U.K.) 128, 2049\u20132062.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_34_2","first-page":"805","volume":"129","year":"2002","unstructured":"Barbieri, A. M., Broccoli, V., Bovolenta, P., Alfano, G., Marchitiello, A., Mocchetti, C., Crippa, L., Bulfone, A., Marigo, V., Ballabio, A., et al. (2002) Development (Cambridge, U.K.) 129, 805\u2013813.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2002.0737"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(99)00132-X"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90246-M"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/377454a0"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1542\/pir.16.12.475"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1177\/10454411920040010201"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)00121-5"},{"key":"e_1_3_2_42_2","first-page":"2755","volume":"128","year":"2001","unstructured":"Schneider, R. A., Hu, D., Rubenstein, J. L., Maden, M. & Helms, J. A. (2001) Development (Cambridge, U.K.) 128, 2755\u20132767.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_43_2","first-page":"1449","volume":"130","year":"2003","unstructured":"Abu\u2013Abed, S., Doll\u00e9, P., Metzger, D., Wood, C., MacLean, G., Chambon, P. & Petkovich, M. (2003) Development (Cambridge, U.K.) 130, 1449\u20131159.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9926(200010)62:4<214::AID-TERA7>3.0.CO;2-N"},{"key":"e_1_3_2_45_2","first-page":"4613","volume":"129","year":"2002","unstructured":"Abu-Issa, R., Smyth, G., Smoak, I., Yamamura, K. & Meyers, E. N. (2002) Development (Cambridge, U.K.) 129, 4613\u20134625.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_46_2","first-page":"2083","volume":"130","year":"2003","unstructured":"Matt, N., Ghyselinck, N. B., Wendling, O., Chambon, P. & Mark, M. (2003) Development (Cambridge, U.K.) 130, 2083\u20132093.","journal-title":"Development (Cambridge, U.K.)"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.1999.2915"},{"key":"e_1_3_2_48_2","unstructured":"Smith B. B. Timm K. I. Huber M. Watrous B. J. & Heidel J. (2000) Alpaca Registry Journal Vol. 5 No. 1 Available at www.alpacaregistry.net\/journal\/spr2000_08.html."}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.2336223100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T09:30:43Z","timestamp":1649842243000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.2336223100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,17]]},"references-count":48,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2003,11,25]]}},"alternative-id":["10.1073\/pnas.2336223100"],"URL":"https:\/\/doi.org\/10.1073\/pnas.2336223100","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,17]]},"assertion":[{"value":"2003-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}