{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:48:00Z","timestamp":1788997680592,"version":"build-2803163510"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"28","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"HHS | NIH | National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS103973"],"award-info":[{"award-number":["R01NS103973"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,7,9]]},"abstract":"<jats:p>\n                    In adult songbirds, new neurons are born in large numbers in the proliferative ventricular zone in the telencephalon and migrate to the adjacent song control region HVC (acronym used as proper name) [A. Reiner\n                    <jats:italic>et al.<\/jats:italic>\n                    ,\n                    <jats:italic>J. Comp. Neurol.<\/jats:italic>\n                    <jats:bold>473<\/jats:bold>\n                    , 377\u2013414 (2004)]. Many of these new neurons send long axonal projections to the robust nucleus of the arcopallium (RA). The HVC\u2013RA circuit is essential for producing stereotyped learned song. The function of adult neurogenesis in this circuit has not been clear. A previous study suggested that it is important for the production of well-structured songs [R. E. Cohen, M. Macedo-Lima, K. E. Miller, E. A. Brenowitz,\n                    <jats:italic>J. Neurosci.<\/jats:italic>\n                    <jats:bold>36<\/jats:bold>\n                    , 8947\u20138956 (2016)]. We tested this hypothesis by infusing the neuroblast migration inhibitor cyclopamine into HVC of male Gambel\u2019s white-crowned sparrows (\n                    <jats:italic>Zonotrichia leucophrys gambelii<\/jats:italic>\n                    ) to block seasonal regeneration of the HVC\u2013RA circuit. Decreasing the number of new neurons in HVC prevented both the increase in spontaneous electrical activity of RA neurons and the improved structure of songs that would normally occur as sparrows enter breeding condition. These results show that the incorporation of new neurons into the adult HVC is necessary for the recovery of both electrical activity and song behavior in breeding birds and demonstrate the value of the bird song system as a model for investigating adult neurogenesis at the level of long projection neural circuits.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2400596121","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T12:55:15Z","timestamp":1720184115000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":5,"title":["Adult neurogenesis is necessary for functional regeneration of a forebrain neural circuit"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1920-923X","authenticated-orcid":false,"given":"Eliot A.","family":"Brenowitz","sequence":"first","affiliation":[{"name":"Department of Psychology, University of Washington, Seattle, WA 98195"},{"name":"Department of Biology, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin L.","family":"Lent","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Washington, Seattle, WA 98195"},{"name":"Department of Biology, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8858-3532","authenticated-orcid":false,"given":"Kimberly E.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Washington, Seattle, WA 98195"},{"name":"Department of Biology, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3142-9614","authenticated-orcid":false,"given":"David J.","family":"Perkel","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Washington, Seattle, WA 98195"},{"name":"Department of Otolaryngology, University of Washington, Seattle, WA 98195"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"542","volume-title":"Neurogenesis","author":"Gage F. 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