{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:19:41Z","timestamp":1793999981310,"version":"4.8.0"},"reference-count":28,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017618","name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["R01DK109539"],"award-info":[{"award-number":["R01DK109539"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,4,2]]},"abstract":"<jats:p>Partial cystectomy procedures for urinary bladder\u2013related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.<\/jats:p>","DOI":"10.1073\/pnas.2400868121","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T13:19:43Z","timestamp":1711631983000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery"],"prefix":"10.1073","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8035-8640","authenticated-orcid":false,"given":"Jihye","family":"Kim","sequence":"first","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208"},{"name":"School of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew I.","family":"Bury","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann &amp; Robert H. 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Querrey Biomedical Research Center, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongha","family":"Kwon","sequence":"additional","affiliation":[{"name":"School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Young","family":"Yoo","sequence":"additional","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208"},{"name":"Department of Semiconductor Convergence Engineering, Sungkyunkwan University, Suwon 16417, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia V.","family":"Halstead","sequence":"additional","affiliation":[{"name":"Division of Pediatric Urology, Department of Surgery, Ann &amp; Robert H. Lurie Children\u2019s Hospital of Chicago, Chicago, IL 60611"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1874-756X","authenticated-orcid":false,"given":"Hee-Sup","family":"Shin","sequence":"additional","affiliation":[{"name":"Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-9369","authenticated-orcid":false,"given":"Shupeng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Min","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of 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