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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:p>\n                    To survive adverse environments, many animals enter a dormant state such as hibernation, dauer, or diapause. Various\n                    <jats:italic>Drosophila<\/jats:italic>\n                    species undergo adult reproductive diapause in response to cool temperatures and\/or short day-length. While flies are less active during diapause, it is unclear how adverse environmental conditions affect circadian rhythms and sleep. Here we show that in diapause-inducing cool temperatures,\n                    <jats:italic>Drosophila melanogaster<\/jats:italic>\n                    exhibit altered circadian activity profiles, including severely reduced morning activity and an advanced evening activity peak. Consequently, the flies have a single activity peak at a time similar to when nondiapausing flies take a siesta. Temperatures \u226415 \u00b0C, rather than photoperiod, primarily drive this behavior. At cool temperatures, flies rapidly enter a deep-sleep state that lacks the sleep cycles of flies at higher temperatures and require high levels of stimulation for arousal. Furthermore, we show that at 25 \u00b0C, flies prefer to siesta in the shade, a preference that is virtually eliminated at 10 \u00b0C. Resting in the shade is driven by an aversion to blue light that is sensed by Rhodopsin 7 outside of the eyes. Flies at 10 \u00b0C show neuronal markers of elevated sleep pressure, including increased expression of Bruchpilot and elevated Ca\n                    <jats:sup>2+<\/jats:sup>\n                    in the R5 ellipsoid body neurons. Therefore, sleep pressure might overcome blue light aversion. Thus, at the same temperatures that cause reproductive arrest, preserve germline stem cells, and extend lifespan,\n                    <jats:italic>D. melanogaster<\/jats:italic>\n                    are prone to deep sleep and exhibit dramatically altered, yet rhythmic, daily activity patterns.\n                  <\/jats:p>","DOI":"10.1073\/pnas.2400964121","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T12:43:44Z","timestamp":1719319424000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Altered circadian rhythm, sleep, and\n                    <i>rhodopsin 7<\/i>\n                    \u2013dependent shade preference during diapause in\n                    <i>Drosophila melanogaster<\/i>"],"prefix":"10.1073","volume":"121","author":[{"given":"Geoff T.","family":"Meyerhof","sequence":"first","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Santa Barbara, CA 93106"},{"name":"Neuroscience Research Institute, University of California, Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4676-2150","authenticated-orcid":false,"given":"Sreesankar","family":"Easwaran","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Santa Barbara, CA 93106"},{"name":"Neuroscience Research Institute, University of California, Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela E.","family":"Bontempo","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Santa Barbara, CA 93106"},{"name":"Neuroscience Research Institute, University of California, Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5637-1482","authenticated-orcid":false,"given":"Craig","family":"Montell","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Santa Barbara, CA 93106"},{"name":"Neuroscience Research Institute, University of California, Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-5925","authenticated-orcid":false,"given":"Denise J.","family":"Montell","sequence":"additional","affiliation":[{"name":"Department of Molecular, Cellular, and Developmental Biology, Santa Barbara, CA 93106"},{"name":"Neuroscience Research Institute, University of California, Santa Barbara, CA 93106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.825057"},{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(00)00238-2"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.66.032102.115105"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2387-5"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-396968-2.00008-7"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells11192929"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20221431"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.245329"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2023.104556"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep11197"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinsphys.2017.01.017"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113051"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28347-z"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msv263"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027493"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28592-2"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2022.01.061"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2023.01.006"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5520"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot5518"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.115.185157"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5439-08.2009"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep40304"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2016.02.011"},{"key":"e_1_3_4_25_2","first-page":"1621","article-title":"A 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Schlichting, P. Menegazzi, M. Rosbash, C. Helfrich-F\u00f6rster, A distinct visual pathway mediates high-intensity light adaptation of the circadian clock in Drosophila. J. Neurosci. 39, 1621\u20131630 (2019).","journal-title":"J. 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T. Meyerhof S. Easwaran A. E. Bontempo C. Montell D. J. Montell Altered circadian rhythm sleep and rhodopsin 7-dependent shade preference during diapause in Drosophila melanogaster. Dryad. https:\/\/datadryad.org\/stash\/share\/ggfdMv3cAqkrI0ZHvidXaxbKe3XF0-QbL746N3hmSZE. 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